osteoclasts

[Mucosal Immunology] Scientists investigated a non-IgE-mediated food-allergic enteropathy model of ovalbumin (OVA) 23-3 mice expressing OVA-specific T-cell-receptor transgenes.

[Cancer Research] Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.

[Nature Communications] Investigators reported that agonists of the immune regulator stimulator of interferon genes (STING) confered remarkable protection against cancer pain, bone destruction, and local tumor burden.

[Scientific Reports] Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.

[Bone Research] The authors demonstrated that global knockout and osteoclast-specific knockout of transcriptional coactivator with PDZ-binding motif (TAZ) led to a low-bone mass phenotype due to elevated osteoclast formation, which was further evidenced by in vitro osteoclast formation assays.

[Cell Death & Disease] Scientists found that exosomal lncRNA-SOX2OT derived from non-small cell lung cancer cells promoted cell invasion and migration in vitro, as well as bone metastasis in vivo.