osteosarcoma cells

[Stem Cells International] SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. Researchers performed in vitro and in vivo assays to determine SOX12 function in osteosarcoma etiology.

[Scientific Reports] Investigators identified the humoral factor involved in the association between tumor cells and surrounding normal cells using a co-culture model and investigated the significance of their findings.

[Molecular Therapy-Oncolytics] The radio-sensitized effect of metformin was investigated, and its mechanism was revealed in CSCs derived from HMPOS, a canine osteosarcoma cell line. Spheroid cells were used as a CSCs rich cells derived from sphere formation and SCs were compared with normal adherent culture cells.

[Oncogene] Investigators identified that osteosarcoma cells commonly exhibit high platelet activation-inducing characteristics, and molecules released from activated platelets promote the invasiveness of osteosarcoma cells.

[Cell Death & Disease] The unique role of cancer/testis antigens (CTAs) in tumor genesis has not yet been verified. Scientists reported the functional role of CT45A1 in the carcinogenesis of osteosarcoma.

[Biochemical and Biophysical Research Communications] The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.