Metformin Preferentially Enhances the Radiosensitivity of Cancer Stem-Like Cells with Highly Mitochondrial Respiration Ability in Canine Osteosarcoma Cell Line

The radio-sensitized effect of metformin was investigated, and its mechanism was revealed in CSCs derived from HMPOS, a canine osteosarcoma cell line. Spheroid cells were used as a CSCs rich cells derived from sphere formation and SCs were compared with normal adherent culture cells.