osteosarcoma cells

[Cell Reports] The rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), was examined, and an inverse correlation between PHGDH expression and relapse-free and overall survival in osteosarcoma patients was found.

[Cell Death & Disease] The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.

[Signal Transduction and Targeted Therapy] Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.

[Signal Transduction and Targeted Therapy] Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.

[British Journal of Cancer] Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.

[Scientific Reports] Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.