Pan-Cancer Analysis Reveals TAp63-Regulated Oncogenic lncRNAs that Promote Cancer Progression through AKT Activation

By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
[Nature Communications]
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., Bedrosian, I., Mitsch, J., Quinlan, P., Thompson, A., Rajapakshe, K., Coarfa, C., Gunaratne, P. H., Marchion, D. C., Magliocco, A. M., Tsai, K. Y., & Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11(1), 5156. https://doi.org/10.1038/s41467-020-18973-w Cite
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TAp63α Targeting of Lgr5 Mediates Colorectal Cancer Stem Cell Properties and Sulforaphane Inhibition

Researchers investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
[Oncogenesis]
Chen, Y., Wang, M., Zhu, J., Xie, C., Li, X., Wu, J., Geng, S., Han, H., & Zhong, C. (2020). TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition. Oncogenesis, 9(10), 1–11. https://doi.org/10.1038/s41389-020-00273-z Cite
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FATS Regulates Polyamine Biosynthesis by Promoting ODC Degradation in an ERβ-Dependent Manner in Non-Small-Cell Lung Cancer

Investigators showed that the presence of the tumor suppressor fragile-site associated tumor suppressor in non-small-cell lung cancer cells led to apoptosis by inducing pro-death autophagy.
[Cell Death & Disease]
Qiu, L., Hu, L., Wang, H., Li, J., Ruan, X., Sun, B., Zhi, J., Zheng, X., Gu, L., Gao, M., Kong, P., & Zhang, J. (2020). FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03052-1 Cite
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Nuclear WRAP53 Promotes Neuronal Survival and Functional Recovery After Stroke

Investigators found that DNA double-strand breaks (DSBs) in oxygen/glucose-deprived neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.
[Science Advances]
Sánchez-Morán, I., Rodríguez, C., Lapresa, R., Agulla, J., Sobrino, T., Castillo, J., Bolaños, J. P., & Almeida, A. (2020). Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. Science Advances, 6(41), eabc5702. https://doi.org/10.1126/sciadv.abc5702 Cite
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Silencing p53 Inhibits Interleukin 10-Induced Activated Hepatic Stellate Cell Senescence and Fibrotic Degradation In Vivo

Scientists explored whether p53 played a crucial role in the senescence of activated hepatic stellate cells and degradation of collagen mediated by interleukin-10.
[Experimental Biology and Medicine]
Guo, Q., Chen, M., Chen, Q., Xiao, G., Chen, Z., Wang, X., & Huang, Y. (2020). Silencing p53 inhibits interleukin 10-induced activated hepatic stellate cell senescence and fibrotic degradation in vivo: Experimental Biology and Medicine. https://doi.org/10.1177/1535370220960391 Cite
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Lysine Demethylase 2A Expression in Cancer-Associated Fibroblasts Promotes Breast Tumor Growth

The expression of lysine demethylase 2A in cancer-associated fibroblasts was studied using immunohistochemical staining and its association with clinicopathological features and patient’s survival was tested.
[British Journal of Cancer]
Chen, J.-Y., Li, C.-F., Lai, Y.-S., & Hung, W.-C. (2020). Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth. British Journal of Cancer, 1–10. https://doi.org/10.1038/s41416-020-01112-z Cite
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Aprea Therapeutics Receives OK from FDA to Initiate Phase 1 Clinical Studies for Next-Generation Mutant p53 Reactivator, APR-548

Aprea Therapeutics, Inc. announced that the FDA has accepted the Company’s Investigational New Drug application for APR-548 to treat TP53 mutant myelodysplastic syndromes. APR-548 is a next-generation small molecule reactivator of mutant p53 that is being developed for oral administration.
[Aprea Therapeutics, Inc.]
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NBS1 Interacts With Notch Signaling in Neuronal Homeostasis

Nbs1 deletion was dispensable for postmitotic neurons, but compromised their arborization and migration due to dysregulated Notch signaling.
[Nucleic Acids Research]
NBS1 interacts with Notch signaling in neuronal homeostasis | Nucleic Acids Research | Oxford Academic. (n.d.). Retrieved October 5, 2020, from https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa716/5917657 Cite
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Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes From Metabolic Exhaustion

Researchers report an epigenetic mechanism contributing to the development of metabolic exhaustion in tumor-infiltrating lymphocytes. Environmental stress produces epigenome remodeling events within tumor-infiltrating lymphocytes resulting from loss of the histone methyltransferase EZH2.
[Cancer Research]
Koss, B., Shields, B. D., Taylor, E. M., Storey, A. J., Byrum, S. D., Gies, A. J., Washam, C. L., Choudhury, S. R., Ahn, J. H., Uryu, H., Williams, J. B., Krager, K. J., Chiang, T.-C., Mackintosh, S. G., Edmondson, R. D., Aykin-Burns, N., Gajewski, T. F., Wang, G. G., & Tackett, A. J. (2020). Epigenetic control of Cdkn2a.Arf protects tumor-infiltrating lymphocytes from metabolic exhaustion. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0524 Cite
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The Therapeutic Effect of the BRD4-Degrading PROTAC A1874 in Human Colon Cancer Cells

A1874-induced degradation of BRD4 protein and downregulated BRD-dependent genes in colon cancer cells. A1874-induced anti-colon cancer cell activity was more potent than the known BRD4 inhibitors. In BRD4-knockout colon cancer cells A1874 remained cytotoxic, indicating the existence of BRD4-independent mechanisms.
[Cell Death & Disease]
Qin, A., Jin, H., Song, Y., Gao, Y., Chen, Y.-F., Zhou, L., Wang, S., & Lu, X. (2020). The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells. Cell Death & Disease, 11(9), 1–12. https://doi.org/10.1038/s41419-020-03015-6 Cite
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The Botanical Component p-Hydroxycinnamic Acid Suppresses the Growth and Bone Metastatic Activity of Human Prostate Cancer PC-3 Cells In Vitro

Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
[Cancer Research]
Yamaguchi, M., Murata, T., & Ramos, J. W. (2020). The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-020-03405-5 Cite
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