By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
6807162 AUF2HCMS items 1 apa default asc 1
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., Bedrosian, I., Mitsch, J., Quinlan, P., Thompson, A., Rajapakshe, K., Coarfa, C., Gunaratne, P. H., Marchion, D. C., Magliocco, A. M., Tsai, K. Y., & Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11(1), 5156. https://doi.org/10.1038/s41467-020-18973-w Cite
Researchers investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
6445212 YF4WI766 items 1 apa default asc 1
Investigators showed that the presence of the tumor suppressor fragile-site associated tumor suppressor in non-small-cell lung cancer cells led to apoptosis by inducing pro-death autophagy.
[Cell Death & Disease]
1254621 TKT9YTGS items 1 apa default asc 1
Qiu, L., Hu, L., Wang, H., Li, J., Ruan, X., Sun, B., Zhi, J., Zheng, X., Gu, L., Gao, M., Kong, P., & Zhang, J. (2020). FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03052-1 Cite
Investigators found that DNA double-strand breaks (DSBs) in oxygen/glucose-deprived neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.
6807162 IZVGL9V9 items 1 apa default asc 1
Scientists explored whether p53 played a crucial role in the senescence of activated hepatic stellate cells and degradation of collagen mediated by interleukin-10.
[Experimental Biology and Medicine]
6445212 7GZ6C9QD items 1 apa default asc 1
The expression of lysine demethylase 2A in cancer-associated fibroblasts was studied using immunohistochemical staining and its association with clinicopathological features and patient’s survival was tested.
[British Journal of Cancer]
Aprea Therapeutics, Inc. announced that the FDA has accepted the Company’s Investigational New Drug application for APR-548 to treat TP53 mutant myelodysplastic syndromes. APR-548 is a next-generation small molecule reactivator of mutant p53 that is being developed for oral administration.
[Aprea Therapeutics, Inc.]
6445212 nan items 1 apa default asc 1
Nbs1 deletion was dispensable for postmitotic neurons, but compromised their arborization and migration due to dysregulated Notch signaling.
[Nucleic Acids Research]
6807162 28C9WA25 items 1 apa default asc 1
NBS1 interacts with Notch signaling in neuronal homeostasis | Nucleic Acids Research | Oxford Academic. (n.d.). Retrieved October 5, 2020, from https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa716/5917657 Cite
Researchers report an epigenetic mechanism contributing to the development of metabolic exhaustion in tumor-infiltrating lymphocytes. Environmental stress produces epigenome remodeling events within tumor-infiltrating lymphocytes resulting from loss of the histone methyltransferase EZH2.
6445218 VPPMPD6A items 1 apa default asc 1
Koss, B., Shields, B. D., Taylor, E. M., Storey, A. J., Byrum, S. D., Gies, A. J., Washam, C. L., Choudhury, S. R., Ahn, J. H., Uryu, H., Williams, J. B., Krager, K. J., Chiang, T.-C., Mackintosh, S. G., Edmondson, R. D., Aykin-Burns, N., Gajewski, T. F., Wang, G. G., & Tackett, A. J. (2020). Epigenetic control of Cdkn2a.Arf protects tumor-infiltrating lymphocytes from metabolic exhaustion. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0524 Cite
A1874-induced degradation of BRD4 protein and downregulated BRD-dependent genes in colon cancer cells. A1874-induced anti-colon cancer cell activity was more potent than the known BRD4 inhibitors. In BRD4-knockout colon cancer cells A1874 remained cytotoxic, indicating the existence of BRD4-independent mechanisms.
[Cell Death & Disease]
Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
6630899 9FYKAAX7 items 1 apa default asc 1