Tag results:

pancreatic cells

Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

Identification of Distinct Slow Mode of Reversible Adaptation of Pancreatic Ductal Adenocarcinoma to the Prolonged Acidic pH Microenvironment

[Journal of Experimental & Clinical Cancer Research] PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment to microenvironmental acidification..

ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction

[Frontiers in Oncology] Pancreatic cancer cells were used to verify the in vitro and in vivo effects of solasonine. Metabolomics were used to evaluate its underlying mechanisms. Solasonine promoted PANC-1 and CFPAC-1 cell apoptosis while inhibiting their proliferation, migration and invasion.

β-Cell Mitochondria in Diabetes Mellitus: A Missing Puzzle Piece in the Generation of hPSC-Derived Pancreatic β-Cells?

[Journal of Translational Medicine] Investigators highlight the role of mitochondria in metabolism secretion coupling in the β-cells and summarize the evidence accumulated for the implication of mitochondria in β-cell dysfunction in diabetes mellitus.

ICA69 Aggravates Ferroptosis Causing Septic Cardiac Dysfunction via STING Trafficking

[Cell Death Discovery] Scientists confirmed that LPS significantly enhanced the expression of islet cell autoantigen 69 (ICA69) in wild-type mice, macrophages, and cardiomyocytes.