Abnormal Exocrine–Endocrine Cell Cross-Talk Promotes β-Cell Dysfunction and Loss in MODY8

Researchers reported the transfer of carboxyl ester lipase proteins from acinar cells to β-cells as a form of cross-talk between exocrine and endocrine cells.
[Nature Metabolism]
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Sodium Butyrate Potentiates Insulin Secretion from Rat Islets at the Expense of Compromised Expression of β Cell Identity Genes

Overlapping analysis of H3K27Ac ChIP-seq and RNA-seq showed that the inhibitory effect of SB on the expression of multiple β cell identity genes was independent of H3K27Ac.
[Cell Death & Disease]
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Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.
[Diabetes]
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Exosomes: The Key of Sophisticated Cell–Cell Communication and Targeted Metastasis in Pancreatic Cancer

In pancreatic cancer, exosomes are enriched with multiple signaling molecules that mediate intercellular communication with control of immune suppression, mutual promotion between pancreas stellate cells and pancreatic cancer cells, and reprogramming of normal cells.
[Cell Communication and Signaling]
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Exposure to Perfluorooctanoic Acid Leads to Promotion of Pancreatic Cancer

Researchers demonstrated that perfluorooctanoic acid induced oxidative stress and focal ductal hyperplasia in the mouse pancreas.
[Carcinogenesis]
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The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.
[Journal of Immunology]
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Subcutaneous Nanotherapy Repurposes the Immunosuppressive Mechanism of Rapamycin to Enhance Allogeneic Islet Graft Viability

Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.
[Nature Nanotechnology]
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Inter-Organ Crosstalk in Pancreatic Islet Function and Pathology

Scientists discuss recent advances in inter-organ communication from the metabolic, immune, and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function, as well as their role in the adaptive responses of islet to nutrition-induced stress.
[Febs Letters]
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Organization and Dynamics of the Cortical Complexes Controlling Insulin Secretion in β-Cells

Researchers showed that insulin secretion sites also contain non-neuronal proteins LL5β and KANK1, which in migrating cells organize exocytotic machinery in the vicinity of integrin-based adhesions.
[Journal of Cell Science]
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ATP Is an Essential Autocrine Factor for Pancreatic β-Cell Signaling and Insulin Secretion

Scientists monitored changes of the intracellular Ca2+ concentration as an immediate read-out for insulin secretion in live cell experiments.
[Physiological Reports]
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LDB1-Mediated Transcriptional Complexes Are Sensitive to Islet Stress

The authors hypothesized that LDB1 and/or ISL1 levels, like other transcriptional regulators, are sensitive to β-cell nutrient and cytokine stresses, likely contributing to β-cell (dys)function under various stimuli.
[Islets]
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