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pancreatic cells

IMB5036 Inhibits Human Pancreatic Cancer Growth Primarily through Activating Necroptosis

[Basic & Clinical Pharmacology & Toxicology] MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.

Regenerative Approaches to Preserve Pancreatic β-Cell Mass and Function in Diabetes Pathogenesis

[Endocrine] Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics.

Tentonin 3/TMEM150C Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

[Cell Reports] Investigators demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributes to glucose-stimulated insulin secretion by mediating cation influx.

ATP-Sensitive Potassium Channels in Zebrafish Cardiac and Vascular Smooth Muscle

[Journal of Physiology] Using a comprehensive combination of genetically modified fish, electrophysiology, and gene expression analysis, scientists demonstrated that zebra fish cardiac myocytes and vascular smooth muscle expressed functional ATP-sensitive potassium channels channels of similar subunit composition, structure, and metabolic sensitivity to their mammalian counterparts.

Glycosylation of MUC6 by α1,4-Linked N-acetylglucosamine Enhances Suppression of Pancreatic Cancer Malignancy

[Cancer Science] Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.

Eugenosedin-A Improves Obesity-Related Hyperglycemia by Regulating ATP-Sensitive K+ Channels and Insulin Secretion in Pancreatic β Cells

[Biomedicine & Pharmacotherapy] The authors isolated pancreatic islets from adult male Wistar rats and identified pancreatic β-cells by the cell size, capacitance and membrane potential.

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