pancreatic cells

[Diabetes] To obtain insight into the role of lipid droplets (LD) in human islet β-cell function, the levels of a key LD scaffold protein, perilipin 2, were manipulated by lentiviral-mediated knockdown or overexpression in EndoCβH2-Cre cells, a human cell line with adult islet β-like properties.

[eLife] Researchers utilized mouse islets to determine how microtubules affect secretion toward the vascular extracellular matrix at single cell and subcellular levels.

[Molecules] Scientists investigated whether the autophagy inhibitor chloroquine could potentiate the anticancer effect of pterostilbene in the PDAC cell lines MIA PaCa-2 and BxPC-3, as well as in an orthotopic animal model.

[Archives of Pharmacal Research] Researchers evaluated the anticancer effect of ACY-241, an HDAC6-selective inhibitor, on erlotinib-resistant pancreatic cancer cells that overexpressed HDAC6.

[Journal of General Physiology] Researchers showed that stepwise increase in extracellular glucose concentration induced electrical activity in β cells of both sexes with similar glucose sensitivity

[Diabetes] Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.