Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.