pancreatic cells

[Endocrinology] Researchers discovered that growth differentiation factor 15 (GDF15) promoted endoplasmic reticulum (ER) stress-induced beta cell apoptosis and that the downregulation of GDF15 has beneficial effects on beta cell survival in diabetes.

[JCI Insight] Scientists found that Notch activation in postnatal β cells impaired glucose-stimulated insulin secretion and glucose intolerance, but also observed a remnant glucose intolerance after doxycycline withdrawal and cessation of Notch activity, associated with a marked disruption of normal islet architecture.

[Molecular Medicine Reports] The authors investigated the role of sigma‑1 receptor (Sig-1R) in islet β‑cell proliferation and examined the effects of Sig‑1R on islet β‑cell injury under lipotoxic conditions.

[Scientific Reports] Scientists characterized non-endocrine cells in iPSC-derived pancreatic islet cells using single-cell transcriptomic analysis and found that non-endocrine cells consisted of heterogeneous proliferating cells, and cells with not only pancreatic traits but also liver or intestinal traits marked by FGB or AGR2.

[Nature Communications] Scientists studied the role of lysosomal Ca2+ in transcription Factor EB (TFEB) activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in pancreatic β-cell function.

[Nature Biotechnology] Investigators generated functionally mature stem-cell-derived islets using an optimized protocol and benchmarked them comprehensively against primary adult islets.