pancreatic cells

[Aging] Scientists characterized a novel pseudogene-miRNA-mRNA network associated with PDAC progression using bioinformatics analysis. After screening by dreamBase and GEPIA, 12 up-regulated and 7 down-regulated differentially expressed pseudogenes were identified.

[Current Opinion in Pharmacology] Glucagon is often administered to counteract severe hypoglycaemia, and commonly used diabetes medications such as GLP-1 analogues, sulfonylureas and SGLT2-inhibitors also affect alpha cells.

[Stem Cell Reports] Scientists described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.

[Cell Reports] Scientists used maturity-onset diabetes of a young 3 patient and CRISPR/Cas9-engineered human induced pluripotent stem cells (hiPSC) grown as 3D organoids to investigate how HNF1αp291fsinsC affected hiPSC differentiation during pancreatic development.

[Nature Metabolism] Mechanistically, the protective role of microsomal prostaglandin E synthase-2 (mPGES-2) deletion was induced by antagonizing β-cell senescence via interference of the PGE2–EP3–NR4A1 signaling axis.

[Free Radical Biology and Medicine] Researchers investigated whether peri-pancreatic white adipose tissue produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity.