An HNF1α Truncation Associated with Maturity-Onset Diabetes of the Young Impairs Pancreatic Progenitor Differentiation by Antagonizing HNF1β Function

Scientists used maturity-onset diabetes of a young 3 patient and CRISPR/Cas9-engineered human induced pluripotent stem cells (hiPSC) grown as 3D organoids to investigate how HNF1αp291fsinsC affected hiPSC differentiation during pancreatic development.