pancreatic ductal adenocarcinoma

[Cell Death & Disease] The authors identified that lysyl oxidase-like 2 was a hypoxia-responsive gene and is essential for the Warburg effect in PDAC.

[Critical Reviews in Oncology Hematology] Cell-free DNA biomarkers indicate accelerated progression and decreased survival in PDAC.

[Clinical Cancer Research] Prospectively generate patient derived organoids were established from a heterogeneous population of patients with pancreatic ductal adenocarcinoma (PDAC) including both basal and classical PDAC subtypes.

[Cell Communication and Signaling] Pancreatic ductal adenocarcinoma is not sensitive to monotherapy with immune checkpoint inhibitors, which might be related to the inhibitory immune microenvironment of pancreatic cancer.

[Cancer Science] Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.

[Nature Communications] Scientists found that 41 and 84 microRNA inhibitors enhanced the sensitivity of Capan1 and MiaPaCa2 pancreatic ductal adenocarcinoma cells respectively.