pancreatic ductal adenocarcinoma

[Scientific Reports] Researchers assessed immunohistochemical p40 expression in fine needle biopsy samples with pancreatic ductal adenocarcinoma and association with cytomorphological features of squamous differentiation and clinical data.

[Cell Biology and Toxicology] Constitutive activation of NF-κB is frequently observed in pancreatic ductal adenocarcinoma (PDAC). Scientists found that YEATS2, a scaffolding protein of ATAC complex, was highly expressed in human PDAC.

[Journal of Biological Chemistry] Investigtors established a system-wide profile of the KRAS-regulated kinase signaling network in KRAS-mutant pancreatic ductal adenocarcinoma.

[Cell Death & Disease] Scientists delineate the key factors in pancreatic ductal adenocarcinoma derived extracellular vesicles that mediate different tumour processes.

[Cell Reports] Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.

[Oncogene] Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.