pancreatic ductal adenocarcinoma

[Scientific Reports] Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.

[Journal of Experimental & Clinical Cancer Research] Researchers investigated the effect of circCUL2 on inflammatory cancer-associated fibroblast activation, heterogeneity and protumor activity by ELISA, flow cytometry, colony formation and transwell assays in vitro and by xenograft models in vivo.

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

[Autoimmunity] Expression of circ_0072088, microRNA (miR)-545-3p and solute carrier family 7 member 11 (SLC7A11) was detected by real-time quantitative PCR and western blotting.

[Journal of Pathology] Pancreatic ductal metaplasia (PDM) development might involve all cell lineages of the pancreas, and acinar cells with the highest plasticity are the major source of PDM.

[Journal of Experimental & Clinical Cancer Research] Researchers investigated the effect of circCUL2 on inflammatory cancer-associated fibroblast activation, heterogeneity and protumor activity by ELISA, flow cytometry, colony formation and transwell assays in vitro and by xenograft models in vivo.