circCUL2 Induces an Inflammatory CAF Phenotype in Pancreatic Ductal Adenocarcinoma via the Activation of the MyD88-Dependent NF-κB Signaling Pathway

Researchers investigated the effect of circCUL2 on inflammatory cancer-associated fibroblast activation, heterogeneity and protumor activity by ELISA, flow cytometry, colony formation and transwell assays ^{in vitro} and by xenograft models ^{in vivo}.