prostate cancer cells

[Journal of Materials Chemistry B] The authors found that the inhibition of Hsp90 could inhibit the overexpression of its client proteins such as anti-apoptotic proteins and androgen receptor, thereby improving the efficacy of photodynamic therapy and inducing prostate cancer cell apoptosis.

[Molecular Cancer Research] Using human cell lines that represent androgen-independent or -sensitive prostate cancer, the authors showed that Mitochondrial Rho GTPase 2 (MIRO2) depletion impaired cell growth, colony formation and tumor growth in mice.

[Journal of Enzyme inhibition and Medicinal Chemistry] The potential synergistic anticancer effect and the underlying mechanisms of roburic acid in combination with docetaxel on prostate cancer were investigated.

[Nature Communications] Researchers sequenced the accessible chromatin regions of 14,424 single-cells from 18 flash-frozen prostate tumors and observed shared chromatin features among low-grade prostate cancer cells are lost in high-grade tumors.

[BMC Cancer] Researchers found that prostate cancer cells appeared to retain their responsiveness to stromal proenkephalin (PENK) signaling. PENK could induce differentiation to counter de-differentiation caused by stem cell transcription factor activation.

[Immunobiology] The authors explored the function and mechanism of LINC00184 in docetaxel resistance of prostate cancer and found that LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulting in upregulation of the expression of PD-L1.