protein expression

[Cell Cycle] Knockout of killin in human colorectal cells led to a dramatic decrease in p53-mediated G1 arrest upon DNA damage.

[Prostate] The authors investigated a combination therapy of novel androgen receptor (AR) antagonists and statin, simvastatin, for CRPC and found that a combination of novel AR antagonists and simvastatin could potentially affect CRPC growth through both androgen-dependent and androgen-independent mechanisms.

[Biochemistry and Cell Biology] Wistar-Kyoto rats and spontaneously hypertensive rats were used to detect the expression of Angptl2. Angiotensin II stimulated vascular smooth muscle cells to mimic hypertension in vitro.

[Bioengineered] Investigators showed that hsa_circ_0030586 was significantly upregulated in prostate cancer (PCa) cells. Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion.

[BMC Cancer] Researchers hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway.

[Life Sciences] The authors examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.