protein expression

[Biochemical and Biophysical Research Communications] The authors evaluated the effects of the autophagy activator AZD8055 on experimental autoimmune encephalomyelitis (EAE). EAE model mice were established, histological examination was performed to assess the degree of inflammatory cell infiltration and demyelination.

[Diabetes] Scientists showed genetic deletion and viral knockdown of hepatocyte-specific endothelial nitric oxide synthase (eNOS) exacerbated hepatic steatosis and inflammation, decreased hepatic mitochondrial fatty acid oxidation and respiration, increased mitochondrial H2O2 emission, and impaired the hepatic mitophagic response.

[Journal of Cellular and Molecular Medicine] Scientists investigated the potential link between DOX-induced cell death and pyroptosis in two human breast cancer cell lines and proved that treatment with DOX reduced cell viability in a dose-dependent way and induced pyroptosis morphology.

[Journal of Experimental & Clinical Cancer Research] Bioinformatic analysis, quantitative mRNA and protein expression analysis, cell models of sarcoma by ectopic expression ofEMX genes. Researchers measured tumorigenesis and populations enriched on stem cell phenotypes, either in vitro or in vivo.

[Radiation Oncology] Scientists analyzed effects of radiation and cetuximab in DU145 and A431 using proliferation, colony-forming-unit- and annexin-V-apoptosis-assays.

[Free Radical Biology and Medicine] Scientists chose a panel of PDAC cell lines with diverse sensitivity to cisplatin and gemcitabine. In PANC-1 chemoresistant cells, they found a low level of oxidative stress and high levels of Nrf2 and YAP protein expressions and their respective targets.