Post-Translational Down-Regulation of Nrf2 and YAP Proteins, by Targeting Deubiquitinases, Reduces Growth and Chemoresistance in Pancreatic Cancer Cells

Scientists chose a panel of PDAC cell lines with diverse sensitivity to cisplatin and gemcitabine. In PANC-1 chemoresistant cells, they found a low level of oxidative stress and high levels of Nrf2 and YAP protein expressions and their respective targets.