Plexin-B2 Orchestrates Collective Stem Cell Dynamics via Actomyosin Contractility, Cytoskeletal Tension and Adhesion

Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.
[Nature Communications]
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Carbon Nanotubes Promote the Development of Intestinal Organoids through Regulating Extracellular Matrix Viscoelasticity and Intracellular Energy Metabolism

The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.
[ACS Nano]
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Astrocytic YAP Prevents the Demyelination through Promoting Expression of Cholesterol Synthesis Genes in Experimental Autoimmune Encephalomyelitis

Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.
[Cell Death & Disease]
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RANBP1 Promotes Colorectal Cancer Progression by Regulating Pre-miRNA Nuclear Export via a Positive Feedback Loop with YAP

Investigators observed high expression of RAN binding protein 1 (RANBP1) in colorectal cancer (CRC) tissues. In vitro and in vivo functional experiments demonstrated that RANBP1 promoted the proliferation and invasion of CRC cells and inhibited the apoptosis of CRC cells.
[Oncogene]
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Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.
[Stem Cells and Development]
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Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice

Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.
[Developmental Cell]
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Cell Proliferation Fate Mapping Reveals Regional Cardiomyocyte Cell-Cycle Activity in Subendocardial Muscle of Left Ventricle

Scientists found that the majority of cycling cardiomyocytes were positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles
[Nature Communications]
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Identification of HMGCR as the Anticancer Target of Physapubenolide against Melanoma Cells by In Silico Target Prediction

Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.
[Acta Pharmaceutica Sinica B]
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Corosolic Acid Inhibits Cancer Progression by Decreasing the Level of CDK19-Mediated O-GlcNAcylation in Liver Cancer Cells

The antitumor ability of corosolic acid (CA) was investigated by inhibiting the O-GlcNAcylation level and its corresponding mechanism. The results showed that high glucose (HG) could promote the proliferation of liver cancer cells, while CA could inhibit cell growth under HG conditions and tumor growth in a xenotransplantation model.
[Cell Death & Disease]
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Long Non-Coding RNA LOC107985656 Represses the Proliferation of Hepatocellular Carcinoma Cells through Activation of the Tumor-Suppressive Hippo Pathway

The lncRNA, mRNA and miRNA levels in hepatocellular carcinoma (HCC) tissues or cells were measured using real-time quantitative polymerase chain reaction. Results showed that LncRNA LOC107985656 was downregulated in HCC tissues and cells.
[Bioengineered]
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A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature

Researchers evaluated matrix metalloproteinase-8 (MMP-8) as a modulator of pathogenic mechanical signaling in pulmonary arterial hypertension (PAH). MMP-8 expression was significantly increased in plasma and pulmonary arteries of pulmonary hypertension (PH) patients compared to controls and induced in the pulmonary vasculature in rodent PH models.
[American Journal of Respiratory and Critical Care Medicine]
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