The authors found that nectin-4 and p95-ErbB2, but not nectin-4 and either ErbB2 or ErbB2∆Ex16, cooperatively enhanced SOX2 gene expression and cell proliferation in a suspension culture.
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Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry]
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Wang, J., Yan, X., Feng, W., Wang, Q., Shi, W., Chai, L., Zhang, Q., Chen, Y., Liu, J., Qu, Z., Xie, X., & Li, M. (2021). S1P induces proliferation of pulmonary artery smooth muscle cell by promoting YAP-induced Notch3 expression and activation. Journal of Biological Chemistry, 0(0). https://doi.org/10.1016/j.jbc.2021.100599 Cite
Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).
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Alderfer, L., Russo, E., Archilla, A., Coe, B., & Hanjaya‐Putra, D. (2021). Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C. The FASEB Journal, 35(5), e21498. https://doi.org/https://doi.org/10.1096/fj.202002426RR Cite
Researchers leveraged the microscale heterogeneity inherent to engineered fiber microenvironments to produce a large morphologic data set, across multiple cells types, while simultaneously measuring mechanobiological response at the single cell level.
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Bonnevie, E. D., Ashinsky, B. G., Dekky, B., Volk, S. W., Smith, H. E., & Mauck, R. L. (2021). Cell morphology and mechanosensing can be decoupled in fibrous microenvironments and identified using artificial neural networks. Scientific Reports, 11(1), 5950. https://doi.org/10.1038/s41598-021-85276-5 Cite
To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells.
[Cancer Management and Research]
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The authors showed that the loss of the junctional scaffold protein MAGI1 was associated with bad prognosis in luminal breast cancer, and promoted tumorigenesis.
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Kantar, D., Mur, E. B., Mancini, M., Slaninova, V., Salah, Y. B., Costa, L., Forest, E., Lassus, P., Géminard, C., Boissière-Michot, F., Orsetti, B., Theillet, C., Colinge, J., Benistant, C., Maraver, A., Heron-Milhavet, L., & Djiane, A. (2021). MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. Scientific Reports, 11(1), 5752. https://doi.org/10.1038/s41598-021-85056-1 Cite
Scientists explored the therapeutic potential of bone marrow-derived mesenchymal stromal cell (BMSC)-derived exosomes against acute lung injury and the underlying mechanisms.
[Acta Pharmacologica Sinica]
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Researchers found that lymph node metastasis (LNM)-gastric cancer (GC) specifically educated bone marrow (BM)-mesenchymal stem cells (MSC) via secretory exosomes. Exosomal Wnt5a was identified as key protein mediating LNM-GCs education of BM-MSCs, which was verified by analysis of serum exosomes collected from GC patients with LNM.
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Wang, M., Zhao, X., Qiu, R., Gong, Z., Huang, F., Yu, W., Shen, B., Sha, X., Dong, H., Huang, J., Wang, L., Zhu, W., & Xu, W. (2021). Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01722-8 Cite
HUVECs were transfected with miR-181a inhibitor/mimic or siRNA-MLL3, or treated with exosomes from hypoxic papillary thyroid cancer cells. Hypoxic exosomal miR-181a delivery promoted proliferation and capillary-like network formation in HUVECs.
[Molecular Therapy-Nucleic Acids]
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Wang, Y., Cen, A., Yang, Y., Ye, H., Li, J., Liu, S., & Zhao, L. (2021). MiR-181a delivered by hypoxic papillary thyroid cancer-secreted exosomes inhibits DACT2 by down-regulating MLL3, leading to YAP-VEGF pathway-mediated angiogenesis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.027 Cite
Researchers identified a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development.
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Scientists demonstrated how targeting SOAT1 promotes YAP expression by elevating cellular cholesterol content in colon cancer cells.
[Cell Death Discovery]
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