YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
[Cancer Research]
Thomann, S., Weiler, S. M. E., Marquard, S., Rose, F., Ball, C. R., Tóth, M., Wei, T., Sticht, C., Fritzsche, S., Roessler, S., Torre, C. D. L., Ryschich, E., Ermakova, O., Mogler, C., Kazdal, D., Gretz, N., Glimm, H., Rempel, E., Schirmacher, P., & Breuhahn, K. (2020). YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0242 Cite
Abstract
Bookmark

No account yet? Register

0
Share

M2 Macrophage-Derived Exosomal-miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/β-Catenin Signalling Axis

M2 macrophage-derived exosomal miR-590-3p reduced inflammatory signals and promoted epithelial regeneration by targeting LATS1 and subsequently activating YAP/β-catenin-regulated transcription
[Journal of Crohns & Colitis]
M2 macrophage-derived exosomal-miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/β-catenin signalling axis | Journal of Crohn’s and Colitis | Oxford Academic. (n.d.). Retrieved October 20, 2020, from https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjaa214/5930684?redirectedFrom=fulltext Cite
Abstract
Bookmark

No account yet? Register

0
Share

Progesterone, via Yes-Associated Protein (YAP), Promotes Cardiomyocyte Proliferation and Cardiac Repair

Progesterone supplementation enhanced cardiomyocyte proliferation in a progesterone receptor‐dependent manner. Progesterone up‐regulated YAP expression and knockdown of YAP by small interfering RNA reduced progesterone‐mediated cardiomyocyte proliferative effect.
[Cell Proliferation]
Lan, C., Cao, N., Chen, C., Qu, S., Fan, C., Luo, H., Zeng, A., Yu, C., Xue, Y., Ren, H., Li, L., Wang, H., Jose, P. A., Xu, Z., & Zeng, C. (n.d.). Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair. Cell Proliferation, n/a(n/a), e12910. https://doi.org/10.1111/cpr.12910 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ERBB2 Drives YAP Activation and EMT-Like Processes During Cardiac Regeneration

Overexpression of activated ERBB2 in cardiomyocytes presented an epithelial-mesenchymal transition-like regenerative response manifested by cytoskeletal remodeling, junction dissolution, migration and ECM turnover.
[Nature Cell Biology]
Aharonov, A., Shakked, A., Umansky, K. B., Savidor, A., Genzelinakh, A., Kain, D., Lendengolts, D., Revach, O.-Y., Morikawa, Y., Dong, J., Levin, Y., Geiger, B., Martin, J. F., & Tzahor, E. (2020). ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00588-4 Cite
Abstract
Bookmark

No account yet? Register

0
Share

ATR Is Essential for Preservation of Cell Mechanics and Nuclear Integrity during Interstitial Migration

ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.
[Nature Communications]
Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Mohamood, A., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., Restuccia, U., Matafora, V., Bachi, A., Barozzi, S., Parazzoli, D., Frittoli, E., Palamidessi, A., Panciera, T., Piccolo, S., … Foiani, M. (2020). ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nature Communications, 11(1), 4828. https://doi.org/10.1038/s41467-020-18580-9 Cite
Press Release
Bookmark

No account yet? Register

0
Share

Nitidine Chloride Possesses Anticancer Property in Lung Cancer Cells through Activating Hippo Signaling Pathway

The authors investigated the anti-tumor functions and the feasible molecular basis of nitidine chloride in NSCLC cells.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

0
Share

ASB13 Inhibits Breast Cancer Metastasis Through Promoting SNAI2 Degradation and Relieving Its Transcriptional Repression of YAP

The authors performed a dual-luciferase-based, genome-wide E3 ligase siRNA library screen and identified ASB13 as an E3 ubiquitin ligase that targeted SNAI2 for ubiquitination and degradation.
[Genes & Development]
Fan, H., Wang, X., Li, W., Shen, M., Wei, Y., Zheng, H., & Kang, Y. (2020). ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes & Development. https://doi.org/10.1101/gad.339796.120 Cite
AbstractPress Release
Bookmark

No account yet? Register

0
Share

YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma

Scientists performed genetic manipulation of Yes-Associated Protein (YAP) in human-derived neuroblastoma cell lines to investigate YAP function in key aspects of the malignant phenotype, including mesenchymal properties, tumor growth, chemotherapy response, and MEK inhibitor response.
[Cancer Research]
Shim, J., Lee, J. Y., Jonus, H. C., Arnold, A., Schnepp, R. W., Janssen, K. M., Maximov, V., & Goldsmith, K. C. (2020). YAP-mediated repression of HRK regulates tumor growth, therapy response, and survival under tumor environmental stress in neuroblastoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0025 Cite
Abstract
Bookmark

No account yet? Register

0
Share

YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice

The authors clarify the unique consequences of YAP/TAZ activation in the ductal cell population of the pancreas by generating mice with pancreatic duct cell-specific, inducible knockouts of Lats1 and Lats2, the main kinases upstream of YAP/TAZ.
[Cancer Research]
Lim, D.-S., Park, J., Eisenbarth, D., Choi, W., Kim, H., Choi, C., & Lee, D. (2020). YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0907 Cite
Abstract
Bookmark

No account yet? Register

0
Share

YAP in Epithelium Senses Gut Barrier Loss to Deploy Defenses against Pathogens

Researchers found that disturbance of the E-cadherin-based adherens junction triggered the nuclear translocation and activation of YAP-1/YAP in the gut of worms. Although YAP is a major downstream effector of the Hippo signaling, their study revealed that the activation of YAP-1/YAP was independent of the Hippo pathway during disruption of intestinal barrier.
[PLoS Pathogens]
Full Article
Bookmark

No account yet? Register

0
Share

Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yap-TEAD Signals

Adult cardiac fibroblasts were freshly isolated and cultured on ECM topographical mimetics for 72 hours. Aligned mimetics caused cardiac fibroblasts to elongate while randomly organized topographies induced circular morphology similar to the disparate myofibroblast morphologies measured in vivo.
[Circulation Research]
Bugg Darrian, Bretherton Ross C, Kim Peter, Olszewski Emily, Nagle Abigail, Schumacher Austin E, Chu Nickolas, Gunaje Jagadambika, DeForest Cole A, Stevens Kelly, Kim Deok-Ho, & Davis Jennifer M. (n.d.). Infarct Collagen Topography Regulates Fibroblast Fate Via p38-Yap-TEAD Signals. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316162 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share