YAP/TAZ Inhibition Reduces Metastatic Potential of Ewing Sarcoma Cells

Investigators suggest that YAP/TAZ pathway inhibition may prevent Ewing sarcoma (EwS) cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.
[Oncogenesis]
Bierbaumer, L., Katschnig, A. M., Radic-Sarikas, B., Kauer, M. O., Petro, J. A., Högler, S., Gurnhofer, E., Pedot, G., Schäfer, B. W., Schwentner, R., Mühlbacher, K., Kromp, F., Aryee, D. N. T., Kenner, L., Uren, A., & Kovar, H. (2021). YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis, 10(1), 1–13. https://doi.org/10.1038/s41389-020-00294-8 Cite
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ALKBH5 Suppresses Tumor Progression via an m6A-Dependent Epigenetic Silencing of Pre-miR-181b-1/Yap Signaling Axis in Osteosarcoma

The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease]
Yuan, Y., Yan, G., He, M., Lei, H., Li, L., Wang, Y., He, X., Li, G., Wang, Q., Gao, Y., Qu, Z., Mei, Z., Shen, Z., Pu, J., Wang, A., Zhao, W., Jiang, H., Du, W., & Yang, L. (2021). ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03315-x Cite
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Establishment of Intestinal Organoid Cultures Modeling Injury-Associated Epithelial Regeneration

Researchers established a novel intestinal organoid culture system composed of 8 components, mainly including VPA, EPZ6438, LDN193189, and R-Spondin 1 conditioned medium, which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury.
[Cell Research]
Qu, M., Xiong, L., Lyu, Y., Zhang, X., Shen, J., Guan, J., Chai, P., Lin, Z., Nie, B., Li, C., Xu, J., & Deng, H. (2021). Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration. Cell Research, 1–13. https://doi.org/10.1038/s41422-020-00453-x Cite
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Rhosin Suppressed Tumor Cell Metastasis through Inhibition of Rho/YAP Pathway and Expression of RHAMM and CXCR4 in Melanoma and Breast Cancer Cells

Researchers investigated the mechanism of metastasis in highly metastatic melanoma and breast cancer cells, and the mechanism of inhibition of metastasis by rhosin.
[Biomedicines]
Tsubaki, M., Genno, S., Takeda, T., Matsuda, T., Kimura, N., Yamashita, Y., Morii, Y., Shimomura, K., & Nishida, S. (2021). Rhosin Suppressed Tumor Cell Metastasis through Inhibition of Rho/YAP Pathway and Expression of RHAMM and CXCR4 in Melanoma and Breast Cancer Cells. Biomedicines, 9(1), 35. https://doi.org/10.3390/biomedicines9010035 Cite
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Transcriptional Activators YAP/TAZ and AXL Orchestrate Dedifferentiation, Cell Fate, and Metastasis in Human Osteosarcoma

To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy]
Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K., McCall, D., Truong, D. D., Cuglievan, B., Menegaz, B. A., Utama, B., Daw, N. C., Molina, E. R., Zielinski, R. J., Livingston, J. A., Gorlick, R., Mikos, A. G., Kim, M. P., & Ludwig, J. A. (2021). Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00281-6 Cite
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Matrix Stiffness Epigenetically Regulates the Oncogenic Activation of the Yes-Associated Protein in Gastric Cancer

Scientists showed that in gastric cancer cells, the stiffness of the ECM reversibly regulates the DNA methylation of the promoter region of the mechanosensitive Yes-associated protein.
[Nature Biomedical Engineering]
Jang, M., An, J., Oh, S. W., Lim, J. Y., Kim, J., Choi, J. K., Cheong, J.-H., & Kim, P. (2020). Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer. Nature Biomedical Engineering, 1–10. https://doi.org/10.1038/s41551-020-00657-x Cite
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Single-Cell Analyses Reveal YAP/TAZ as Regulators of Stemness and Cell Plasticity in Glioblastoma

Investigators used single-cell datasets and identified glioma stem cells (GSC) at the apex of the differentiation hierarchy of glioblastoma (GBM). By reconstructing the GSCs’ regulatory network, they identified the YAP/TAZ coactivators as master regulators of this cell state, irrespectively of GBM subtypes.
[Nature Cancer]
Castellan, M., Guarnieri, A., Fujimura, A., Zanconato, F., Battilana, G., Panciera, T., Sladitschek, H. L., Contessotto, P., Citron, A., Grilli, A., Romano, O., Bicciato, S., Fassan, M., Porcù, E., Rosato, A., Cordenonsi, M., & Piccolo, S. (2020). Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma. Nature Cancer, 1–15. https://doi.org/10.1038/s43018-020-00150-z Cite
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Proline-Rich Tyrosine Kinase 2 Mediates Transforming Growth Factor-Beta-Induced Hepatic Stellate Cell Activation and Liver Fibrosis

The impact of ECM on TGF-β-mediated fibrogenic signaling pathway in hepatic stellate cells (HSCs) has remained obscure. Investigators studied the role of non-receptor tyrosine kinase focal adhesion kinase family members in TGF-β-signaling in HSCs.
[Scientific Reports]
Kim, J., Kang, W., Kang, S. H., Park, S. H., Kim, J. Y., Yang, S., Ha, S. Y., & Paik, Y.-H. (2020). Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Scientific Reports, 10(1), 21018. https://doi.org/10.1038/s41598-020-78056-0 Cite
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Borax Induces Osteogenesis by Stimulating NaBC1 Transporter via Activation of BMP Pathway

The intrinsic properties of MSCs make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ECMs and/or include soluble factors in the media. Scientists propose a simple approach based on ion transporter stimulation to determine stem cell fate that avoids the use of growth factors.
[Communications Biology]
Rico, P., Rodrigo-Navarro, A., Sánchez Pérez, L., & Salmeron-Sanchez, M. (2020). Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway. Communications Biology, 3(1), 1–15. https://doi.org/10.1038/s42003-020-01449-4 Cite
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Low-Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity

While both acute low-intensity vibrations and lysophosphohaditic acid treatments increased nuclear YAP entry by 50 and 87% over the basal levels in simulated microgravity(SMG)-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls.
[npj Microgravity]
Thompson, M., Woods, K., Newberg, J., Oxford, J. T., & Uzer, G. (2020). Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity. Npj Microgravity, 6(1), 1–11. https://doi.org/10.1038/s41526-020-00125-5 Cite
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FRMD6 has Tumor Suppressor Functions in Prostate Cancer

In overexpression and CRISPR/Cas9 knockout experiments in prostate cancer cell lines, FRMD6 inhibited viability, proliferation, cell cycle progression, colony formation, 3D spheroid growth, and tumor xenograft growth in mice.
[Oncogene]
Haldrup, J., Strand, S. H., Cieza-Borrella, C., Jakobsson, M. E., Riedel, M., Norgaard, M., Hedensted, S., Dagnaes-Hansen, F., Ulhoi, B. P., Eeles, R., Borre, M., Olsen, J. V., Thomsen, M., Kote-Jarai, Z., & Sorensen, K. D. (2020). FRMD6 has tumor suppressor functions in prostate cancer. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01548-w Cite
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