Multi-Omic Analysis Reveals Divergent Molecular Events in Scarring and Regenerative Wound Healing

Scientists profiled scarring versus YAP-inhibition-induced wound regeneration at the transcriptional, protein, and tissue levels, and showed that disrupting YAP mechanotransduction yielded regenerative repair by fibroblasts with activated Trps1 and Wnt signaling.
[Cell Stem Cell]
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Hippo Signaling in the Liver: Role in Development, Regeneration and Disease

The authors summarize the diverse roles of Hippo signaling in liver biology and highlight areas where outstanding questions remain to be investigated.
[Nature Reviews Gastroenterology & Hepatology]
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Trehangelins Ameliorate Inflammation-Induced Skin Senescence by Suppressing the Epidermal YAP-CCN1 Axis

Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).
[Scientific Reports]
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RICH1 Inhibits Breast Cancer Stem Cell Traits through Activating Kinases Cascade of Hippo Signaling by Competing with Merlin for Binding to Amot-p80

Scientists found that the low expression of RICH1 in breast cancer was associated with poor prognosis. Depletion of RICH1 promoted the stemness and disrupted the normal epithelial architecture of MCF10A cells.
[Cell Death & Disease]
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Signaling by the Tyrosine Kinase Yes Promotes Liver Cancer Development

Researchers reported the identification of a previously uncharacterized oncogenic signaling pathway in hepatocellular carcinoma that was mediated by the tyrosine kinase Yes.
[Science Signaling]
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Coordinate Control of Basal Epithelial Cell Fate and Stem Cell Maintenance by Core EMT Transcription Factor Zeb1

Investigators reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative capacity.
[Cell Reports]
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Role, Molecular Mechanism and the Potential Target of Breast Cancer Stem Cells in Breast Cancer Development

Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.
[Biomedicine & Pharmacotherapy]
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CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports]
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Adaptive Differentiation Promotes Intestinal Villus Recovery

Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.
[Developmental Cell]
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Hypoxia-Induced Fascin-1 Upregulation Is Regulated by Akt/Rac1 Axis and Enhances Malignant Properties of Liver Cancer Cells via Mediating Actin Cytoskeleton Rearrangement and Hippo/Yap Activation

Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.
[Cell Death Discovery]
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Current Hydrogel Advances in Physicochemical and Biological Response-Driven Biomedical Application Diversity

Scientists concisely introduce the physicochemical properties of hydrogels and their fabrication approaches.
[Signal Transduction and Targeted Therapy]
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