YAP/TAZ Suppress Drug Penetration into Hepatocellular Carcinoma via Stromal Activation

Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
[Hepatology]
Cho, K., Ro, S. W., Lee, H. W., Moon, H., Han, S., Kim, H. R., Ahn, S. H., Park, J. Y., & Kim, D. Y. (n.d.). YAP/TAZ suppress drug penetration into hepatocellular carcinoma via stromal activation. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.32000 Cite
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MPDZ as a Novel Epigenetic Silenced Tumor Suppressor Inhibits Growth and Progression of Lung Cancer through the Hippo-YAP Pathway

The tumor suppressing effects of MPDZ were determined in vitro and in vivo. The target molecules and signaling pathway that mediated the function of MPDZ were also identified.
[Oncogene]
Liu, W., Huang, Y., Wang, D., Han, F., Chen, H., Chen, J., Jiang, X., Cao, J., & Liu, J. (2021). MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway. Oncogene, 1–18. https://doi.org/10.1038/s41388-021-01857-8 Cite
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Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
[Nature Communications]
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RAB11A-Mediated YAP Localization to Adherens and Tight Junctions Is Essential for Colonic Epithelial Integrity

Scientists examined the relationship of RAB11A to epithelial junctional complexes, YAP, and the associated consequences on colonic epithelial tissue repair.
[Journal of Biological Chemistry]
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High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
[Proceedings of the National Academy of Sciences of the United States of America]
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R. O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., Eyss, B. von, Sigal, M., & Birchmeier, W. (2021). High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53. Proceedings of the National Academy of Sciences, 118(22). https://doi.org/10.1073/pnas.2019699118 Cite
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Anti-Tumor Effect of Trametinib in Bladder Cancer Organoid and the Underlying Mechanism

In each bladder cancer organoid strain, epidermal growth factor receptor/ERK signaling was upregulated compared with normal bladder cells.
[Cancer Biology & Therapy]
Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., & Sasaki, K. (2021). Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biology & Therapy, 0(0), 1–15. https://doi.org/10.1080/15384047.2021.1919004 Cite
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Small-Molecule Inhibition of Lats Kinases May Promote Yap-Dependent Proliferation in Postmitotic Mammalian Tissues

Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.
[Nature Communications]
Kastan, N., Gnedeva, K., Alisch, T., Petelski, A. A., Huggins, D. J., Chiaravalli, J., Aharanov, A., Shakked, A., Tzahor, E., Nagiel, A., Segil, N., & Hudspeth, A. J. (2021). Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nature Communications, 12(1), 3100. https://doi.org/10.1038/s41467-021-23395-3 Cite
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A miR-375/YAP Axis Regulates Neuroendocrine Differentiation and Tumorigenesis in Lung Carcinoid Cells

Investigators identified and elucidated the function of a miR-375/yes-associated protein axis in lung carcinoid (H727) cells.
[Scientific Reports]
Yang, X., Nanayakkara, J., Claypool, D., Saghafinia, S., Wong, J. J. M., Xu, M., Wang, X., Nicol, C. J. B., Michael, I. P., Hafner, M., Yang, X., & Renwick, N. (2021). A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells. Scientific Reports, 11(1), 10455. https://doi.org/10.1038/s41598-021-89855-4 Cite
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AAV-Mediated YAP Expression in Cardiac Fibroblasts Promotes Inflammation and Increases Fibrosis

Researchers leveraged adeno-associated virus (AAV) to target cardiac fibroblasts and demonstrated that chronic Yes-associated protein (YAP) expression upregulated indices of fibrosis and inflammation in the absence of additional stress.
[Scientific Reports]
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A Spatial Model of YAP/TAZ Signaling Reveals How Stiffness, Dimensionality, and Shape Contribute to Emergent Outcomes

Researchers developed a spatial model of YAP/TAZ translocation to enable quantitative analysis of the relationships between substrate stiffness, substrate dimensionality, and cell shape.
[Proceedings of the National Academy of Sciences of the United States of America]
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Targeting Cholesterol Biosynthesis Promotes Anti-Tumor Immunity by Inhibiting Long Noncoding RNA SNHG29 Mediated YAP Activation

Researchers found that simvastatin inhibited PD-L1 expression and promoted anti-tumor immunity via suppressing the expression of lncRNA SNHG29.
[Molecular Therapy]
Ni, W., Mo, H., Liu, Y., Xu, Y., Qin, C., Zhou, Y., Li, Y., Li, Y., Zhou, A., Yao, S., Zhou, R., Huo, J., Che, L., & Li, J. (2021). Targeting Cholesterol Biosynthesis Promotes Anti-tumor Immunity by Inhibiting Long Noncoding RNA SNHG29 Mediated YAP Activation. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.05.012 Cite
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