Nectin-4 and p95-ErbB2 Cooperatively Regulate Hippo Signaling-Dependent SOX2 Gene Expression, Enhancing Anchorage-Independent T47D Cell Proliferation

The authors found that nectin-4 and p95-ErbB2, but not nectin-4 and either ErbB2 or ErbB2∆Ex16, cooperatively enhanced SOX2 gene expression and cell proliferation in a suspension culture.
[Scientific Reports]
Kedashiro, S., Kameyama, T., Mizutani, K., & Takai, Y. (2021). Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation. Scientific Reports, 11(1), 7344. https://doi.org/10.1038/s41598-021-86437-2 Cite
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S1P Induces Proliferation of Pulmonary Artery Smooth Muscle Cell by Promoting YAP-Induced notch3 Expression and Activation

Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry]
Wang, J., Yan, X., Feng, W., Wang, Q., Shi, W., Chai, L., Zhang, Q., Chen, Y., Liu, J., Qu, Z., Xie, X., & Li, M. (2021). S1P induces proliferation of pulmonary artery smooth muscle cell by promoting YAP-induced Notch3 expression and activation. Journal of Biological Chemistry, 0(0). https://doi.org/10.1016/j.jbc.2021.100599 Cite
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Matrix Stiffness Primes Lymphatic Tube Formation Directed by Vascular Endothelial Growth Factor-C

Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).
[FASEB Journal]
Alderfer, L., Russo, E., Archilla, A., Coe, B., & Hanjaya‐Putra, D. (2021). Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C. The FASEB Journal, 35(5), e21498. https://doi.org/https://doi.org/10.1096/fj.202002426RR Cite
AbstractPress Release
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Cell Morphology and Mechanosensing Can Be Decoupled in Fibrous Microenvironments and Identified Using Artificial Neural Networks

Researchers leveraged the microscale heterogeneity inherent to engineered fiber microenvironments to produce a large morphologic data set, across multiple cells types, while simultaneously measuring mechanobiological response at the single cell level.
[Scientific Reports]
Bonnevie, E. D., Ashinsky, B. G., Dekky, B., Volk, S. W., Smith, H. E., & Mauck, R. L. (2021). Cell morphology and mechanosensing can be decoupled in fibrous microenvironments and identified using artificial neural networks. Scientific Reports, 11(1), 5950. https://doi.org/10.1038/s41598-021-85276-5 Cite
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LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with LINC-PINT

To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells.
[Cancer Management and Research]
Ji, L., Chen, S., Gu, L., Wang, J., & Zhang, X. (2021). <p>LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with LINC-PINT</p>. Cancer Management and Research, 13, 2153–2161. https://doi.org/10.2147/CMAR.S260371 Cite
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MAGI1 Inhibits the AMOTL2/p38 Stress Pathway and Prevents Luminal Breast Tumorigenesis

The authors showed that the loss of the junctional scaffold protein MAGI1 was associated with bad prognosis in luminal breast cancer, and promoted tumorigenesis.
[Scientific Reports]
Kantar, D., Mur, E. B., Mancini, M., Slaninova, V., Salah, Y. B., Costa, L., Forest, E., Lassus, P., Géminard, C., Boissière-Michot, F., Orsetti, B., Theillet, C., Colinge, J., Benistant, C., Maraver, A., Heron-Milhavet, L., & Djiane, A. (2021). MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. Scientific Reports, 11(1), 5752. https://doi.org/10.1038/s41598-021-85056-1 Cite
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BMSC-Derived Exosomes Ameliorate Sulfur Mustard-Induced Acute Lung Injury by Regulating the GPRC5A–YAP Axis

Scientists explored the therapeutic potential of bone marrow-derived mesenchymal stromal cell (BMSC)-derived exosomes against acute lung injury and the underlying mechanisms.
[Acta Pharmacologica Sinica]
Mao, G., Gong, C., Wang, Z., Sun, M., Pei, Z., Meng, W., Cen, J., He, X., Lu, Y., Xu, Q., & Xiao, K. (2021). BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00625-4 Cite
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Lymph Node Metastasis-Derived Gastric Cancer Cells Educate Bone Marrow-Derived Mesenchymal Stem Cells via YAP Signaling Activation by Exosomal Wnt5a

Researchers found that lymph node metastasis (LNM)-gastric cancer (GC) specifically educated bone marrow (BM)-mesenchymal stem cells (MSC) via secretory exosomes. Exosomal Wnt5a was identified as key protein mediating LNM-GCs education of BM-MSCs, which was verified by analysis of serum exosomes collected from GC patients with LNM.
[Oncogene]
Wang, M., Zhao, X., Qiu, R., Gong, Z., Huang, F., Yu, W., Shen, B., Sha, X., Dong, H., Huang, J., Wang, L., Zhu, W., & Xu, W. (2021). Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01722-8 Cite
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MiR-181a Delivered by Hypoxic Papillary Thyroid Cancer-Secreted Exosomes Inhibits DACT2 by Down-Regulating MLL3, Leading to YAP-VEGF Pathway-Mediated Angiogenesis

HUVECs were transfected with miR-181a inhibitor/mimic or siRNA-MLL3, or treated with exosomes from hypoxic papillary thyroid cancer cells. Hypoxic exosomal miR-181a delivery promoted proliferation and capillary-like network formation in HUVECs.
[Molecular Therapy-Nucleic Acids]
Wang, Y., Cen, A., Yang, Y., Ye, H., Li, J., Liu, S., & Zhao, L. (2021). MiR-181a delivered by hypoxic papillary thyroid cancer-secreted exosomes inhibits DACT2 by down-regulating MLL3, leading to YAP-VEGF pathway-mediated angiogenesis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.027 Cite
AbstractFull ArticleGraphical Abstract
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Mechanochemical Control of Epidermal Stem Cell Divisions by B-Plexins

Researchers identified a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development.
[Nature Communications]
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Cholesterol Activates the Wnt/PCP-YAP Signaling in SOAT1-Targeted Treatment of Colon Cancer

Scientists demonstrated how targeting SOAT1 promotes YAP expression by elevating cellular cholesterol content in colon cancer cells.
[Cell Death Discovery]
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