protein expression

[Journal of Molecular Endocrinology] A mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the TRAIL pathway was investigated in cultured cells and isolated mouse islets.

[Frontiers in Cell and Developmental Biology] Single-cell RNA sequencing was performed with human induced pluripotent stem cell-derived cardiomyocytes and endothelial cells in mono- and co-culture.

[Cell] Investigators characterized the proteogenomic landscape of lung squamous cell carcinoma (LSCC), providing a deeper exposition of LSCC biology with potential therapeutic implications.

[Cell] Rhythmic segmented filamentous bacteria (SFB) attachment was driven by the circadian clock through control of feeding rhythms. Mechanistically, rhythmic SFB attachment activated an immunological circuit involving group 3 innate lymphoid cells.

[Oncogene] Researchers reported that the expression of CRYβB2 in breast cancer cells increased stemness, growth, and metastasis. Transcriptomics data revealed that CRYβB2 upregulated genes that were functionally associated with unfolded protein response, oxidative phosphorylation, and DNA repair, while down-regulating genes related to apoptosis.

[Cancer Letters] MICAL1 gene disruption by CRISPR/Cas9 in MDA MB 231 human breast cancer cells knocked out protein expression, which affected F-actin organization, cell size and motility.