protein expression

[International Immunopharmacology] Scientists showed that TNF-α significantly reduced the expression of SIRT6 protein and mRNA in a concentration- and time-dependent manner and increased the expression of monocyte chemotactic protein 1, interleukin (IL) -6 and IL-1β in human umbilical vein endothelial cells.

[Cell Death & Disease] The authors identified a novel long non-coding RNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients.

[Oncogene] Researchers found that fat mass and obesity-associated (FTO) protein levels, but not RNA levels, were downregulated in colorectal cancer (CRC) tissues. Reduced FTO protein expression was correlated with a high recurrence rate and poor prognosis in resectable CRC patients.

[Journal of Molecular Endocrinology] Researchers investigated the mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway in cultured cells and isolated mouse islets.

[Chemico-Biological Interactions] Researchers investigated the synergistic effects of pelargonic acid vanillylamide and rosuvastatin on ox-LDL-induced inflammatory responses in human vascular endothelial cells.

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.