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pulmonary cells

Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis

[Cell Biochemistry and Biophysics] Researchers investigated the role of lysocardiolipin acyltransferase expression and activity in mitochondrial oxidative stress, mitochondrial dynamics, and lung epithelial cell apoptosis.

Nrf2 Attenuates Ferroptosis-Mediated IIR-ALI by Modulating TERT and SLC7A11

[Cell Death & Disease] Researchers found that telomerase reverse transcriptase (TERT) was significantly reduced in lung tissue of Nrf2−/− mice in the model of intestinal ischemia/reperfusion-induced acute lung injury (IIR-ALI)

ABL Allosteric Inhibitors Synergize with Statins to Enhance Apoptosis of Metastatic Lung Cancer Cells

[Cell Reports] The ABL tyrosine kinases promote metastasis, and enhanced ABL signaling is associated with a poor prognosis in lung adenocarcinoma patients. Researchers showed that ABL kinase allosteric inhibitors impaired mitochondrial integrity and decrease oxidative phosphorylation.

Ultrastructural Changes Associated to the Neuroendocrine Transdifferentiation of the Lung Adenocarcinoma Cell Line A549

[Acta Histochemica] Researchers identified the morphological characteristics of the neuroendocrine phenotype in a human lung cancer cell line, induced by two cAMP elevating agents.

Gene Transfer of MRCKα Rescues Lipopolysaccharide-Induced Acute Lung Injury by Restoring Alveolar Capillary Barrier Function

[Scientific Reports] Researchers investigated whether electroporation-mediated gene transfer of MRCKα to the lungs can attenuate LPS-induced acute lung injury in vivo.

TCTP Protein Degradation by Targeting mTORC1 and Signaling through S6K, Akt, and Plk1 Sensitizes Lung Cancer Cells to DNA-Damaging Drugs

[Scientific Reports] Researchers investigated the role of mTORC1 in regulating translationally controlled tumor protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model.

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