ABL Allosteric Inhibitors Synergize with Statins to Enhance Apoptosis of Metastatic Lung Cancer Cells

The ABL tyrosine kinases promote metastasis, and enhanced ABL signaling is associated with a poor prognosis in lung adenocarcinoma patients. Researchers showed that ABL kinase allosteric inhibitors impaired mitochondrial integrity and decrease oxidative phosphorylation.