Chronic Intermittent Hypoxia Promoted Lung Cancer Stem Cell-Like Properties via Enhancing Bach1 Expression

Scientists observed that chronic intermittent hypoxia endowed lung cancer with greater metastatic potential, evidenced by increased tumor growth, tumor seeding, and upregulated cancer stem cells-related gene expression in the lungs.
[Respiratory Research]
Hao, S., Zhu, X., Liu, Z., Wu, X., Li, S., Jiang, P., & Jiang, L. (2021). Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression. Respiratory Research, 22(1), 58. https://doi.org/10.1186/s12931-021-01655-6 Cite
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Exploitation of the Vitamin A/Retinoic Acid Axis Depletes ALDH1-Positive Cancer Stem Cells and Re-Sensitizes Resistant Non-Small Cell Lung Cancer Cells to Cisplatin

The authors investigated the function of the cancer stem cell marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
[Translational Oncology]
MacDonagh, L., Santiago, R. M., Gray, S. G., Breen, E., Cuffe, S., Finn, S. P., O’Byrne, K. J., & Barr, M. P. (2021). Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin. Translational Oncology, 14(4), 101025. https://doi.org/10.1016/j.tranon.2021.101025 Cite
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Urinary Malate Dehydrogenase 2 Is a New Biomarker for Early Detection of Non‐Small Cell Lung Cancer

Scientists demonstrate that the urinary malate dehydrogenase 2 concentration is higher in early‐stage NSCLC patients than that in controls and may serve as a potential biomarker for the early detection of non‐small cell lung cancer.
[Cancer Science]
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USP9X-Mediated KDM4C Deubiquitination Promotes Lung Cancer Radioresistance by Epigenetically Inducing TGF-β2 Transcription

Investigators provide evidence that genetic or pharmacological inhibition of lysine-specific demethylase 4C (KDM4C) impairs tumorigenesis and radioresistance in lung cancer in vitro and in vivo.
[Cell Death & Differentiation]
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Distinct Mechanisms for TMPRSS2 Expression Explain Organ-Specific Inhibition of SARS-CoV-2 Infection by Enzalutamide

Scientists evaluated the antiviral efficacy of enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and Ad-ACE2-transduced mice.
[Nature Communications]
Li, F., Han, M., Dai, P., Xu, W., He, J., Tao, X., Wu, Y., Tong, X., Xia, X., Guo, W., Zhou, Y., Li, Y., Zhu, Y., Zhang, X., Liu, Z., Aji, R., Cai, X., Li, Y., Qu, D., … Gao, D. (2021). Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nature Communications, 12(1), 866. https://doi.org/10.1038/s41467-021-21171-x Cite
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Progress on Pivotal Role and Application of Exosome in Lung Cancer Carcinogenesis, Diagnosis, Therapy and Prognosis

Several studies are currently underway to develop novel diagnostic and prognostic modalities using lung cancer cell-derived exosomes (LCCDEs), and to develop methods of exploiting exosomes for use as efficient drug delivery vehicles. Current status of lung cancer and extensive applicability of LCCDEs are illustrated in this review.
[Molecular Cancer]
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Circular RNA FLNA Acts as a Sponge of miR-486-3p in Promoting Lung Cancer Progression via Regulating XRCC1 and CYP1A1

Investigators found that miR-486-3p was low-expressed in lung cancer. miR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells.
[Cancer Gene Therapy]
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Secretoglobin 3A2 Eliminates Human Cancer Cells through Pyroptosis

Researchers showed that secretoglobin 3A2 exhibits marked anti-cancer activity against 5 out of 11 of human non-small cell lung cancer cell lines in mouse xenographs, while no effect was observed in 6 of 6 small cell lung cancer cell lines examined.
[Cell Death Discovery]
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Extracellular Vesicles‐Encapsulated let‐7i Shed from Bone Mesenchymal Stem Cells Suppress Lung Cancer via KDM3A/DCLK1/FXYD3 Axis

Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
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Intermittent Hypoxia-Induced Downregulation of MicroRNA-320b Promotes the Lung Cancer Tumorigenesis by Increasing CDT1 via USP37

Scientists explored the functional roles of microRNAs in lung cancer patients that were complicated with obstructive sleep apnea-hypopnea involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined.
[Molecular Therapy-Nucleic Acids]
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Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

Researchers integrated the data from a selective drug screen in epithelial and mesenchymal Kras/p53 mutant lung tumor cells with separate datasets including reverse phase protein array and an in vivo shRNA dropout screen.
[Cancer Research]
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