Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer

The authors report that glutamate transporters, in particular SLC1A1, were tightly intertwined with cystine uptake and glutathione biosynthesis in lung cancer cells.
[Cancer Research]
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TGFβ Promotes YAP‐Dependent AXL Induction in Mesenchymal‐Type Lung Cancer Cells

Researchers revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, they also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression.
[Molecular Oncology]
Choi, J.-Y., Lee, H., Kwon, E.-J., Kong, H.-J., Kwon, O.-S., & Cha, H.-J. (n.d.). TGFβ promotes YAP-dependent AXL induction in mesenchymal-type lung cancer cells. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12857 Cite
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Medicinal Potential of Mycelium and Fruiting Bodies of an Arboreal Mushroom Fomitopsis officinalis in Therapy of Lifestyle Diseases

Researchers aimed to investigate the antiproliferative activity of mycelium extracts and F. officinalis sporocarps against the the DU145 prostate cancer cell line, a melanoma cell line and a lung cancer cell line.
[Scientific Reports]
Fijałkowska, A., Muszyńska, B., Sułkowska-Ziaja, K., Kała, K., Pawlik, A., Stefaniuk, D., Matuszewska, A., Piska, K., Pękala, E., Kaczmarczyk, P., Piętka, J., & Jaszek, M. (2020). Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases. Scientific Reports, 10(1), 20081. https://doi.org/10.1038/s41598-020-76899-1 Cite
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OTUD7B Suppresses Smac Mimetic-Induced Lung Cancer Cell Invasion and Migration via Deubiquitinating TRAF3

Scientists assessed lung cancer cell elongation, invasion and migration under treatment with the Smac mimetic LCL161. Functional analyses (in vitro and in vivo) were performed to detect the contribution of NIK and OTUD7B to LCL161-induced cell invasion and migration. The role of OTUD7B in regulation of the TRAF3/NIK/NF-κB pathway under LCL161 treatment was analysed by immunoblotting, immunoprecipitation, luciferase and ubiquitin assays, shRNA silencing and plasmid overexpression. Expression levels of OTUD7B, NIK and TRAF3 in tissue samples from lung cancer patients were examined by immunohistochemistry.
[Journal of Experimental & Clinical Cancer Research]
Zhang, B., Yang, C., Wang, R., Wu, J., Zhang, Y., Liu, D., Sun, X., Li, X., Ren, H., & Qin, S. (2020). OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3. Journal of Experimental & Clinical Cancer Research, 39(1), 244. https://doi.org/10.1186/s13046-020-01751-3 Cite
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Induction of NEDD8-Conjugating Enzyme E2 UBE2F by Platinum Protects Lung Cancer Cells from Apoptosis and Confers to Platinum-Insensitivity

Researchers report that the upregulation of the NEDD8-conjugating enzyme UBE2F is an important way for lung cancer cells to escape platinum-induced cell apoptosis, which confers to insensitivity to platinum-based chemotherapy.
[Cell Death & Disease]
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Amplified LncRNA PVT1 Promotes Lung Cancer Proliferation and Metastasis by Facilitating VEGFC Expression

Elevated levels of plasmacytoma variant translocation 1 (PVT1) promoted lung cancer cell proliferation and metastasis, both in vitro and in vivo. Mechanistically, scientists found that PVT1 competed endogenously with miR-128 in the regulation of vascular endothelial growth factor C expression, which was significantly associated with an unfavorable prognosis in lung cancer.
[Biochemistry and Cell Biology]
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Therapeutic Potential of Polysaccharide of Ipomoea batatas as an Autophagy Inducer for Treating Lung Cancer via Blocking PAK1/Akt/mTOR Signaling

Researchers identified a role of Ipomoea batatas polysaccharides (IBP) in inhibiting lung cancer proliferation. They found that IBP significantly impeded the proliferation of lung cancer cells by inducing cytostatic macroautophagy both in vitro and in vivo.
[Molecular Therapy-Oncolytics]
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SASH1 Is a Prognostic Indicator and Potential Therapeutic Target in Non-Small Cell Lung Cancer

Scientists showed that low SAM and SH3 domain-containing protein 1 (SASH1) mRNA expression was associated with poor survival in adenocarcinoma. Supporting this, modulation of SASH1 levels in a panel of lung cancer cell lines mediated changes in cellular proliferation and sensitivity to cisplatin.
[Scientific Reports]
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Plasma-Activated Medium as Adjuvant Therapy for Lung Cancer with Malignant Pleural Effusion

Researchers compared effects of plasma-activated medium with effects of conventional clinical thermal therapy on both lung cancer cells and benign cells for management of malignant pleural effusion.
[Scientific Reports]
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Importin 13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

The authors identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]
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Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma

75% of adenocarcinomas lack targeted therapies due to scarcity of druggable drivers. The authors classified tumors based on signaling similarities and discovered subgroups within this unmet patient population.
[Clinical Cancer Research]
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