Regulation of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.
[Scientific Reports]
Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J., Heyl, D., & Evans, H. G. (2021). Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific Reports, 11(1), 9708. https://doi.org/10.1038/s41598-021-88574-0 Cite
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ALK Inhibition Activates LC3B-Independent, Protective Autophagy in EML4-ALK Positive Lung Cancer Cells

Investigators asked whether ALK inhibition affected autophagy, and whether this might influence treatment response.
[Scientific Reports]
Schläfli, A. M., Tokarchuk, I., Parejo, S., Jutzi, S., Berezowska, S., Engedal, N., & Tschan, M. P. (2021). ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells. Scientific Reports, 11(1), 9011. https://doi.org/10.1038/s41598-021-87966-6 Cite
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Schisandrin B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling Pathways

established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that Schisandrin B inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.
[Oncology Reports]
Li, S., Wang, H., Ma, R., & Wang, L. (2021). Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways. Oncology Reports, 45(6), 1–13. https://doi.org/10.3892/or.2021.8066 Cite
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DNAJC12 Promotes Lung Cancer Growth by Regulating the Activation of β-Catenin

Scientists revealed that the dnaJ heat shock protein family (HSP40) member C12 (DNAJC12) expression levels were significantly upregulated in lung cancer tissues compared with non‑cancer lung tissues.
[International Journal of Molecular Medicine]
Li, Y., Li, M., Jin, F., Liu, J., Chen, M., & Yin, J. (2021). DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin. International Journal of Molecular Medicine, 47(6), 1–11. https://doi.org/10.3892/ijmm.2021.4938 Cite
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Anti-cancer & Anti-metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
[Amb Express]
Noorbazargan, H., Amintehrani, S., Dolatabadi, A., Mashayekhi, A., Khayam, N., Moulavi, P., Naghizadeh, M., Mirzaie, A., Mirzaei rad, F., & Kavousi, M. (2021). Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express, 11(1), 61. https://doi.org/10.1186/s13568-021-01216-6 Cite
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Schisandrin B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling Pathways

Investigators established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that SchB inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.
[Oncology Reports]
Li, S., Wang, H., Ma, R., & Wang, L. (2021). Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways. Oncology Reports, 45(6), 1–13. https://doi.org/10.3892/or.2021.8066 Cite
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Purpurin, a Anthraquinone Induces ROS-Mediated A549 Lung Cancer Cell Apoptosis via Inhibition of PI3K/AKT and Proliferation

Scientists evaluated purpurin, a natural biomedicine and a potential inhibitor in decreasing the growth rate of lung cancer cells by modulating the role of PI3K/AKT signalling-associated proliferation and apoptosis.
[Journal of Pharmacy and Pharmacology]
Bo, S., Lai, J., Lin, H., Luo, X., Zeng, Y., & Du, T. (2021). Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation. Journal of Pharmacy and Pharmacology, rgab056. https://doi.org/10.1093/jpp/rgab056 Cite
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Enhanced Cell Death Effects of MAP Kinase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Increased ROS Levels and GSH Depletion

Researchers investigated the effects of mitogen-activated protein kinase (MAPK; MEK, JNK, and p38) inhibitors on PG-treated Calu-6 and A549 lung cancer cells in relation to cell death as well as reactive oxygen species (ROS) and glutathione (GSH) levels.
[Toxicology in Vitro]
Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion. (2021). Toxicology in Vitro, 74, 105176. https://doi.org/10.1016/j.tiv.2021.105176 Cite
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αvβ3 Integrin Induces Partial EMT Independent of TGF-β Signaling

Investigators demonstrated that αvβ3 integrin induced partial epithelial–mesenchymal transition, which was characterized by acquiring mesenchymal phenotypes while retaining epithelial markers.
[Communications Biology]
Kariya, Y., Oyama, M., Suzuki, T., & Kariya, Y. (2021). αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Communications Biology, 4(1), 1–11. https://doi.org/10.1038/s42003-021-02003-6 Cite
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SOD1 Regulates Ribosome Biogenesis in KRAS Mutant Non-small Cell Lung Cancer

Researchers describeed the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model.
[Nature Communications]
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Tubulin Acetylation Enhances Lung Cancer Resistance to Paclitaxel-Induced Cell Death through Mcl-1 Stabilization

Investigators showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel resistance.
[Cell Death Discovery]
Wattanathamsan, O., Thararattanobon, R., Rodsiri, R., Chanvorachote, P., Vinayanuwattikun, C., & Pongrakhananon, V. (2021). Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00453-9 Cite
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