The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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Applying DrugSniper to SCLC, scientists identified genes extensively explored in SCLC. The analysis suggested a remarkable vulnerability to polo-like kinase 1 inhibition in CREBBP-mutant SCLC cells.
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Carazo, F., Bértolo, C., Castilla, C., Cendoya, X., Campuzano, L., Serrano, D., … Rubio, A. (2020). DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC). Cancers, 12(7), 1824. https://doi.org/10.3390/cancers12071824 Cite
Distribution of LINC02323 was detected by the nuclear‐plasma separation experiment. Cell proliferation was assessd by MTT assay, and cell migration and invation were detected by transwell assays.
Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
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Binding of V(V) or V(IV) to transferrin in cell culture medium drastically reduced its cellular uptake and antiproliferative activity in the A549 cell line that expresses transferrin receptor 1.
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Significant upregulation of Bcl-2 was found in AZD9291-resistant H1975 cells compared with H1975, which may constitute an important resistant mechanism of acquired resistance to AZD9291.
[Archives of Toxicology]
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Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
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