TCTP Protein Degradation by Targeting mTORC1 and Signaling through S6K, Akt, and Plk1 Sensitizes Lung Cancer Cells to DNA-Damaging Drugs

Researchers investigated the role of mTORC1 in regulating translationally controlled tumor protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model.