pulmonary cells

[European Journal of Pharmaceutical Sciences] Scientists evaluated in vitro drug release, in vitro cytotoxicity on A549 lung cancer cells, nebulization performance using next generation impactor, and the in vivo biodistribution behavior.

[Inflammation] The authors evaluated the effects of the association between Cryptococcus neoformans and Dermatophagoides pteronyssinus in the modulation of airway inflammatory responses in an in vitro experimental model using human bronchial epithelial cells.

[International Journal of Molecular Medicine] The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.

[Cell Death & Disease] Researchers identified neurokinin-1 as a significantly upregulated GPCR in the transcriptome and tissue array of human lung cancer samples, associated with advanced clinical stages and poor prognosis.

[International Journal of Biological Sciences] Researchers found that decreased expression of ITGB4 was negatively correlated with the level of MUC5AC in childhood airway epithelial cells following respiratory syncytial virus (RSV) infection.

[International Journal of Biological Sciences] By applying untargeted global metabolomics approach, the authors showed that arsenic was highly capable of perturbing the intracellular metabolic programs of the human bronchial epithelial cells, some of which were prominent hallmarks of cancer cell metabolism.