regulatory T cells

[Scientific Reports] The authors developed, characterized and assessed whether chimeric heavy chain only antibodies against CTLA4 were viable therapeutic candidates for the treatment of canine cancers.

[Arteriosclerosis Thrombosis and Vascular Biology] In the mouse aortocaval fistula model, anti-PD-L1 antibody was given to inhibit PD-L1 activity during arteriovenous fistulae maturation.

[Life Sciences] Infiltration and activity of CD8+ T cells is reduced in hypoxic conditions, whereas regulatory T cells and myeloid-derived suppressor cells show high activities.

[Frontiers of Medicine] Investigators systematically profiled chromatin accessibility on Th1, Th2, Th1-17, Th17, and Treg cells and found that chromatin remodeling contributed significantly to the pathogenesis of the disease.

[Nature Communications] Scientists developed a strategy to compare the epigenetic and transcriptional make-up of primary glioblastoma cells with patient-matched expanded potential stem cell (EPSC)-derived neural stem cells.

[Nanoscale] The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.