Adoptive CD8+T-Cell Grafted with Liposomal Immunotherapy Drugs to Counteract the Immune Suppressive Tumor Microenvironment and Enhance Therapy for Melanoma

The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.