regulatory T cells

[Nature Immunology] The authors described a new autoregulatory loop whereby ThPOK bound to the SilThPOK to maintain its own long-term expression in CD4 T cells.

[Advanced Healthcare Materials] A preprocessing strategy was developed to reprogram the immunosuppressive tumor microenvironment using a thermoresponsive hydrogel loaded with doxorubicin.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

[EMBO Reports] Investigators used whole-genome analyses to show that the transcriptional program and epigenetic features of Treg cells were attenuated in the absence of Tet2 and Tet3.

[Scientific Reports] Scientists observed a reduction in the levels of CD4+ T cells and an increase in both the polymorphonuclear MDSCs and Tregs.

[Science] Given the well-established role of CD4 T cells in sustaining germinal centers (GCs) and the emerging role of Foxp3 in suppressing this reaction, scientists sought to determine whether expression of Foxp3 by GC-resident T cells could also play a role in GC longevity.