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Pulmonary Cell NewsGiven the well-established role of CD4 T cells in sustaining germinal centers (GCs) and the emerging role of Foxp3 in suppressing this reaction, scientists sought to determine whether expression of Foxp3 by GC-resident T cells could also play a role in GC longevity.
[Science]
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Jacobsen, J. T., Hu, W., Castro, T. B. R., Solem, S., Galante, A., Lin, Z., Allon, S. J., Mesin, L., Bilate, A. M., Schiepers, A., Shalek, A. K., Rudensky, A. Y., & Victora, G. D. (2021). Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science, 373(6552). https://doi.org/10.1126/science.abe5146 Cite
