regulatory T cells

[Nature Reviews Immunology] IL-2 biologics have proven to be effective in preclinical studies and clinical assessment of some is now underway.

[Communications Biology] Researchers used a humanized mouse model to show that while carboplatin plus pembrolizumab reduced tumor growth moderately and transiently, the addition of the tumor suppressor gene TUSC2, delivered systemically in nanovesicles, to this combination, eradicates tumors in the majority of animals.

[Scientific Reports] Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied.

[Scientific Reports] Researchers examined whether haem oxygenase-1 (HO-1) could enhance the immunosuppressive effects of bone marrow MSCs (BMMSCs) on the rejection of transplanted liver allografts in rats.

[PLoS Biology] Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance.

[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.