rheumatoid arthritis

[Nature Reviews Rheumatology] Scientists propose an architecture for such a joint-on-chip (JoC) platform, discuss the status of the engineering of individual joint tissues and the efforts to combine them in a functional JoC model and identify unresolved issues and challenges in constructing an accurate, physiologically relevant system.

[Molecular Immunology] Scientists investigated the therapeutic effect of miR-223 in exosomes secreted by bone marrow MSCs on immune response in the progression of rheumatoid arthritis.

[Scandinavian Journal of Rheumatology] Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with rheumatoid arthritis.

[Annals of the Rheumatic Diseases] The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.

[Science Signaling] Investigators demonstrated that cytoplasmic, bioavailable zinc was essential for promoting IL-1β production in activated human monocytes and macrophages downstream of glycolysis induced by the kinase-containing multiprotein complex mTORC1.

[Stem Cell Research & Therapy] Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs.