Cytoplasmic Zinc Promotes IL-1β Production by Monocytes and Macrophages through mTORC1-Induced Glycolysis in Rheumatoid Arthritis

Investigators demonstrated that cytoplasmic, bioavailable zinc was essential for promoting IL-1β production in activated human monocytes and macrophages downstream of glycolysis induced by the kinase-containing multiprotein complex mTORC1.