sarcoma cells

[Journal of Biomedical Science] NKX6-1 enhanced in vitro tumor cell aggressiveness via upregulation of cell proliferation and anchorage-independent growth and promoted in vivo tumor growth.

[Oncogenesis] Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.

[Scientific Reports] Scientists evaluated the effects of Lithocholic bile acid (LCA) on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used.

[Oncogene] Investigators showed that the expression of the RRM2 protein is dependent on active protein synthesis and that 4E-BP1, a repressor of cap-dependent protein translation, specifically regulates the level of the ribonucleotide reductase (RRM2) protein.

[Cell Death & Disease] Silencing of GARP in bone sarcoma cell lines blocked their proliferation and induced apoptosis. In contrast, overexpression of GARP promoted their growth in vitro and in vivo and increased their resistance to DNA damage and cell death induced by etoposide, doxorubicin, and irradiation.