sarcoma

[Histopathology] In extrauterine low-grade endometrial stromal sarcoma (LG-ESS), the positive rate of JAZF1 gene rearrangement was significantly lower than in uterine LG-ESS, limiting the value of JAZF1 gene translocation for diagnosis.

[Aadi Bioscience, Inc.] Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO™ for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.

[Nature Reviews Disease Primers] VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.

[Scientific Reports] Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).

[Rakovina Therapeutics, Inc.] Rakovina Therapeutics, Inc. announced that the company has been selected to join a three year US $975,000 research program funded by the St. Baldrick’s Foundation Martha’s BEST Grant for All, which is aimed at developing new treatments for Ewing sarcoma, an aggressive bone and soft tissue cancer in children and young adults.

[Cancer Letters] The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.