SARS-CoV-2

[Science Translational Medicine] Vaccinated individuals who tested positive showed higher mucosal antibody responses in nasal secretions and higher Spike protein-specific CD8+ T cell responses in peripheral blood than did vaccinated individuals who tested negative.

[Journal of Clinical Microbiology] Investigators discuss what Correlates of Protections are, review the current understanding of infection-induced, vaccine-elicited and hybrid immunity to COVID-19 and summarize the current and potential future utility of SARS-CoV-2 serologic testing.

[Cell Reports] Using glycan engineering and epitope scaffolding in boosting immunogens, scientists focused murine serum antibody responses to conserved receptor binding motif and domain epitopes following SARS-CoV-2 spike imprinting.

[Cell Reports Medicine] The authors used blood transcriptomics, multiparameter flow cytometry, and T cell receptor sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses.

[Autophagy] Researchers identified ORF3a as an inducer of autophagy and revealed that ORF3a localized to the ER and induced RETREG1/FAM134B-related reticulophagy through the HMGB1-BECN1 pathway.

[Nature Medicine] Investigators reported the results of the open-label, non-randomized part B of a Phase II trial in which they evaluated the safety and immunogenicity of a booster injection of 50 µg of the COVID-19 vaccine mRNA-1273 in 344 adult participants immunized 6–8 months earlier with a primary series of two doses of 50 µg or 100 µg of mRNA-1273.