SARS-CoV-2 ORF3a Induces RETREG1/FAM134B-Dependent Reticulophagy and Triggers Sequential ER Stress and Inflammatory Responses during SARS-CoV-2 Infection

Researchers identified ORF3a as an inducer of autophagy and revealed that ORF3a localized to the ER and induced RETREG1/FAM134B-related reticulophagy through the HMGB1-BECN1 pathway.