SARS-CoV-2

[Cell Reports] Scientists identified SARS-CoV-2 RNA-dependent RNA-polymerase as highly conserved likely due to its critical role in the virus life cycle.

[Nature Communications] Scientists performd a comprehensive analysis of the plasma proteome of more than 1400 proteins in children with SARS-CoV-2. They showed that protein signatures demonstrated overlap between multi-system inflammatory syndrome in children, and the inflammatory syndromes macrophage activation syndrome and thrombotic microangiopathy.

[Cell Death Discovery] Researchers investigated species-specific cell susceptibility, virus dose-dependent infectivity, and infection kinetics, using primary human and porcine respiratory epithelial cells.

[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.

[Signal Transduction and Targeted Therapy] The authors combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.

[Science Advances] Investigators found that triggering receptor expressed on myeloid cells 2 (TREM-2) was induced in T cells in the blood and lungs of patients with COVID-19.