schizophrenia

[Translational Psychiatry] Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.

[Otsuka Pharmaceutical Co., Ltd. (BusinessWire, Inc.)] Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S reported that the US FDA has accepted a Supplemental New Drug Application for the treatment of schizophrenia in adolescents with Rexulti® and has granted Otsuka and Lundbeck Priority Review.

[Nature Reviews Neuroscience] Researchers discuss how developmental pruning programs may go awry in neurodevelopmental disorders of the human CNS, focusing on autism spectrum disorder and schizophrenia.

[Teva Pharmaceuticals, Ltd. (BusinessWire, Inc.)] Teva Pharmaceuticals, and MedinCell announced that the New Drug Application for TV-46000/mdc-IRM for the treatment of schizophrenia has been accepted by the US FDA

[Neuropsychopharmacology] Researchers show that reduced BDNF and GABA also co-occur with attenuated autophagy in human depression.

[Cell Death Discovery] There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.