The Proteomic Architecture of Schizophrenia iPSC-Derived Cerebral Organoids Reveals Alterations in GWAS and Neuronal Development Factors

Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.