single-cell RNA sequencing

[Molecular Metabolism] Scientists utilized sorting of physically interacting cells with single-cell RNA-sequencing to systematically map cellular interactions in the endocrine pancreas after pancreatectomy.

[Hepatology] Investigators applied selection strategies to enrich innate lymphoid cells (ILC) populations in hepatocellular carcinoma (HCC) samples to investigate the effects of B cells on the immune reaction of ICOS+ ILC2 cells.

[Haematologica] By combining single cell analyses and P53 conformation-specific monoclonal antibodies scientists studied pre-leukemic-HSCs/progenitor cells from primary human DNMT3A-mutated AML samples.

[PLoS Computational Biology] Researchers applied IQCELL to single cell RNA-seq datasets from early mouse T cell and red blood cell development, and showed that the platform could infer overall over 74% of causal gene interactions previously reported from decades of research.

[Cell Death & Disease] The authors performed flow cytometry and single-cell RNA sequencing to examine the immune cell landscape of excisional wounds from Angptl4+/+ and Angptl4−/− mice.

[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.