smooth muscle cells

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

[Pulmonary Pharmacology & Therapeutics] Researchers investigated the effects of PCI-34051-induced human bronchial epithelial cells-derived exosomes on human bronchial smooth muscle cells and the key exosomal miRNAs involved in this process.

[Circulation Research] Using smooth muscle cells (SMCs), mouse models, and human atherosclerosis specimens, scientists found that focal adhesion kinase (FAK) activation elicited SMC dedifferentiation by stabilizing DNA methyltransferase 3A.

[Journal of Cellular and Molecular Medicine] The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.

[Metabolic Brain Disease] Scientists explored the detailed role and mechanism of circRNA LIF receptor subunit alpha in human umbilical artery smooth muscle cells.

[European Journal of Clinical Investigation] The authors summarize current knowledge about vascular smooth muscle cells (vSMCs) functions within the aortic wall and give an overview of how vSMC functions are dysregulated in aortic aneurysms and aortic dissections pathogenesis, organized per anatomical location.