smooth muscle cells

[Journal of Biological Chemistry] USP10 expression was detected in mouse arteries and increased after carotid ligation. In vitro data showed that USP10 deficiency reduced proliferation and migration of rat thoracic aorta smooth muscle cells (A7r5) and human aortic smooth muscle cells (HASMCs).

[Kaohsiung Journal of Medical Sciences] Scientists found that lncRNA XIST was related to the abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs), and thus, the mechanism by which XIST regulated HVSMCs was further investigated.

[Human Pathology] The apoptosis of smooth muscle cells is a major feature of thoracic aortic aneurysm. Scientists investigated the roles of circ_0091434 in human aortic smooth muscle cells.

[Pflugers Archiv-European Journal of Physiology] Scientists explored the effects of β2-adrenergic stimulation by isoproterenol on vascular smooth muscle cells (VSMC) calcification. Experiments were performed in primary human aortic VSMCs treated with isoproterenol during control or high phosphate conditions.

[Cardiovascular Research] Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.

[American Journal of Respiratory and Critical Care Medicine] Researchers evaluated matrix metalloproteinase-8 (MMP-8) as a modulator of pathogenic mechanical signaling in pulmonary arterial hypertension (PAH). MMP-8 expression was significantly increased in plasma and pulmonary arteries of pulmonary hypertension (PH) patients compared to controls and induced in the pulmonary vasculature in rodent PH models.