smooth muscle cells

[Molecular Therapy-Nucleic Acids] Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.

[International Journal of Molecular Medicine] Scientists determined the role and mechanism of circRNA‑glutamate metabotropic receptor 1 in pulmonary artery smooth muscle cell proliferation and migration in hypoxic pulmonary hypertension.

[Journal of Translational Medicine] The authors investigated whether mitofusin-2 (Mfn-2) gene related peptide enhanced apoptotic activities to inhibit vascular smooth muscle cell accumulation and neointimal hyperplasia in rats with carotid balloon injury.

[Journal of Molecular and Cellular Cardiology] Investigators performed single-cell profiling of 35,245 cells from two venous malformation samples and three cavernous venous malformation samples, with a focus on endothelial cells, smooth muscle cells and immune microenvironment.

[Stem Cell Reports] The authors developed a robust multi-cell type 3D vessel-on-chip model based entirely on human induced pluripotent stem cells (hiPSCs). Within a fibrin hydrogel microenvironment, the hiPSC-derived vascular cells self-organized to form stable microvascular networks reproducibly, in which the vessels were lumenized and functional, responding as expected to vasoactive stimulation.

[American Journal of Physiology-Heart and Circulatory Physiology] Researchers aimed to identify the differential expression of intracellular and exosomal miRNA in human VSMCs (hVSMCs) during replicative senescence by isolating intracellular and exosomal miRNAs from hVSMCs and subsequently subjecting them to whole-genome small RNA next-generation sequencing, bioinformatics analysis and qPCR validation.