smooth muscle cells

[Molecular Medicine Reports] Scientists elucidated the functions of miR‑125a‑5p and miR‑7 in vascular smooth muscle cells and investigated the associated molecular mechanisms.

[Environmental Science and Pollution Research] Researchers examined the effects of Stmn2 on phenotype transformation of vascular smooth muscle in vascular injury via RNA sequencing and experimental validation.

[Scientific Reports] Researchers demonstrated cyclic compression of primary human endothelial cells, fibroblasts, and smooth muscle cells to show physiological changes in their morphology due to applied forces.

[Nature Aging] The authors found that senescent cells inhibited vascular smooth muscle cells (VSMCs) promigratory phenotype switching in the first interfiber space of the arterial wall directly beneath the atherosclerotic plaque, thereby limiting lesion entry of medial VSMCs for fibrous cap assembly or reinforcement.

[Acta Pharmacologica Sinica] Scientists revealed that MK2206 suppressed migration, proliferation, and inflammation in vascular smooth muscle cells. Moreover, MK2206 inhibited proliferation and inflammation of endothelial cells.

[AAPS Journal] Scientists summarize the current understanding of exosome biogenesis and uptake, and discuss atherogenic and atheroprotective functions of exosomes secreted from these cell types.