Tag results:
stem cell markers
Hepatic Cell News
Loss of Numb Promotes Hepatic Progenitor Expansion and Intrahepatic Cholangiocarcinoma by Enhancing Notch Signaling
[Cell Death & Disease] Numb silencing in cultured intrahepatic cholangiocarcinoma cells enhanced cell spheroid growth, invasion, metastasis, and the expression of stem cell markers.
Cancer Stem Cell News
Fine-Tuned Repression of Drp1 Driven Mitochondrial Fission Primes a ‘Stem/Progenitor-Like State’ to Support Neoplastic Transformation
[eLife] Using a newly derived carcinogen transformed human cell model, researchers demonstrated that fine-tuned Drp1 repression primed a slow cycling 'stem/progenitor-like state', which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
Cancer Stem Cell News
Cancerous and Non-Neoplastic Stem Cells in the Stomach Similarly Express CD44 and CD133
[Acta Histochemica] Scientists investigated the expression of CD44 and CD133 in gastric cancer and non-neoplastic gastric mucosa. They used samples of primary gastric adenocarcinomas, metastatic lymph nodes, intestinal metaplasia, and histologically normal gastric tissues of surgical margins.
Mammary Cell News
lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing a6 Integrin/CD49f Expression in Breast Cancer Stem Cells
[Molecular Cancer Research] To elucidate the underlying mechanisms that drive breast cancer stem cells (BCSCs) tumorigenicity in TNBC, scientists identified the long noncoding RNA BMP/OP-Responsive Gene (BORG) as an enhancer of BCSC phenotypes.
Cancer Stem Cell News
Chronic Exposure to FGF2 Converts iPSCs into Cancer Stem Cells with an Enhanced Integrin/Focal Adhesion/PI3K/AKT Axis
[Cancer Letters] Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.
Cancer Stem Cell News
Long Noncoding RNA LINC00261 Upregulates ITIH5 to Impair Tumorigenic Ability of Pancreatic Cancer Stem Cells
[Cell Death Discovery] Researchers investigated the mechanism by which lncRNA LINC00261 affected the biological functions of cancer stem cells during the progression of pancreatic cancer.