stroke

[Nature Communications] Investigators developed a cell-adhesive fiber-forming peptide that mimicked the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial ECM for regenerative therapy.

[Cell Death & Disease] By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.

[Toxicology and Applied Pharmacology] Scientists used human iPSC-derived embryoid bodies as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds.

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

[Translational Psychiatry] A post-stroke depression (PSD)-like model was established by treating neuronal cells with oxygen-glucose deprivation and corticosterone. Scientists found that protein pro-brain-derived neurotrophic factor (BDNF) levels were higher in the cortex and hippocampus in the PSD group than in the controls.

[Stroke] Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. Researchers found that CHIP was associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.