Transmembrane Protein 97 Exhibits Oncogenic Properties via Enhancing LRP6-Mediated Wnt Signaling in Breast Cancer

Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
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Pantoprazole Ameliorates Liver Fibrosis and Suppresses Hepatic Stellate Cell Activation in Bile Duct Ligation Rats by Promoting YAP Degradation

Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.
[Acta Pharmacologica Sinica]
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CCT245718, a Dual FLT3/Aurora a Inhibitor Overcomes D835Y-Mediated Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia Cells

The ability of CCT245718 to overcome TKD-mediated resistance was evaluated in a cell line-based model of drug resistance to Fms-like tyrosine kinase 3 (FLT3) inhibitors.
[British Journal of Cancer]
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Drivers and Suppressors of Triple-Negative Breast Cancer

Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
[Proceedings of the National Academy of Sciences of the United States of America]
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A Proteogenomic Portrait of Lung Squamous Cell Carcinoma

Investigators characterized the proteogenomic landscape of lung squamous cell carcinoma (LSCC), providing a deeper exposition of LSCC biology with potential therapeutic implications.
[Cell]
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VALD-3, a Schiff Base Ligand Synthesized from O-Vanillin Derivatives, Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells by Inhibiting the Wnt/β-Catenin Pathway

Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.
[Scientific Reports]
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Diagnostic and Prognostic Potential of the Proteomic Profiling of Serum-Derived Extracellular Vesicles in Prostate Cancer

Investigators exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays, to measure key antigens and activated signaling in extracellular vesicles isolated from sera of prostate cancer patients.
[Cell Death & Disease]
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In Vitro Assessment of a Synergistic Combination of Gemcitabine and Zebularine in Pancreatic Cancer Cells

Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
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Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity and Tumor-Immune Evolution in Refractory Mantle Cell Lymphoma

The authors characterized the cellular and molecular heterogeneity within and across patients and delineate the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders.
[Nature Communications]
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STAT3/SH3PXD2A-AS1/miR-125b/STAT3 Positive Feedback Loop Affects Psoriasis Pathogenesis via Regulating Human Keratinocyte Proliferation

SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.
[Cytokine]
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Bone Marrow Mesenchymal Stromal Cells can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis

Scientists investigated the significance of this mode of immune-escape on T cells engineered to express chimeric antigen receptors (CAR-T) cells.
[Clinical Cancer Research]
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