Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.
[Acta Pharmacologica Sinica]
[zotpress userid=’7992332′ items=’ANEAH8B9′ style=’apa’ cite=’yes’]
The ability of CCT245718 to overcome TKD-mediated resistance was evaluated in a cell line-based model of drug resistance to Fms-like tyrosine kinase 3 (FLT3) inhibitors.
[British Journal of Cancer]
[zotpress userid=’7992332′ items=’DL6RLTR4′ style=’apa’ cite=’yes’]
Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’7992332′ items=’6EH5IP6F’ style=’apa’ cite=’yes’]
Investigators characterized the proteogenomic landscape of lung squamous cell carcinoma (LSCC), providing a deeper exposition of LSCC biology with potential therapeutic implications.
[zotpress userid=” items=’ZACKV6MM’ style=’apa’ cite=’yes’]
Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.
[zotpress userid=’7992332′ items=’YHPHHD45′ style=’apa’ cite=’yes’]
Investigators exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays, to measure key antigens and activated signaling in extracellular vesicles isolated from sera of prostate cancer patients.
[Cell Death & Disease]
[zotpress userid=” items=’CKY3HKF9′ style=’apa’ cite=’yes’]
Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
[zotpress userid=’7753456′ items=’9DJJDIZ8′ style=’apa’ cite=’yes’]
The authors characterized the cellular and molecular heterogeneity within and across patients and delineate the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders.
[zotpress userid=” items=’MT8ZC3A7′ style=’apa’ cite=’yes’]
SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.
[zotpress userid=’7753456′ items=’8SVUQ45P’ style=’apa’ cite=’yes’]
Scientists investigated the significance of this mode of immune-escape on T cells engineered to express chimeric antigen receptors (CAR-T) cells.
[Clinical Cancer Research]
[zotpress userid=’6445212′ items=’YHQNEWS9′ style=’apa’ cite=’yes’]