IMV Announces First Patient Dosed in the VITALIZE Phase IIB Clinical Study Evaluating its Lead Compound, MVP-S, in Combination with KEYTRUDA® (pembrolizumab) in Patients with r/r DLBCL

IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.
[IMV Inc.]
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Combined Effect of Heat Shock Protein Inhibitor Geldanamycin and Free Radicals on Photodynamic Therapy of Prostate Cancer

The authors found that the inhibition of Hsp90 could inhibit the overexpression of its client proteins such as anti-apoptotic proteins and androgen receptor, thereby improving the efficacy of photodynamic therapy and inducing prostate cancer cell apoptosis.
[Journal of Materials Chemistry B]
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STAT3 as a Target for Sensitizing Prostate Cancer Cells to Irradiation

Investigators demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of prostate cancer (PCa) cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks than radiation alone in LNCaP cells.
[Radiation Research]
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Galactose-Decorated Liver Tumor-Specific Nanoliposomes Incorporating Selective BRD4-Targeted PROTAC for Hepatocellular Carcinoma Therapy

Researchers suggested that galactosylated nanoliposomes incorporating ARV-825 was a novel actively targeted PROTAC-based nanotherapeutic approach for hepatocellular carcinoma.
[Heliyon]
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Manuka Honey in Combination with 5-Fluorouracil Decreases Physical Parameters of Colonspheres Enriched with Cancer Stem-Like Cells and Reduces Their Resistance to Apoptosis

Scientists evaluated the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate.
[Food Chemistry]
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Overcoming Prostate Cancer Drug Resistance with a Novel Organosilicon Small Molecule

A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. GH1504 exhibited potent in vitro cytotoxicity in a broad spectrum of human cancer cells, including PCa cells refractory to ADT and chemotherapy.
[Neoplasia]
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Survivin Expression Is Essential for Early Activation of Hepatic Stellate Cells and Fibrosis Progression in Chronic Liver Injury

Researchers investigated the role of survivin protein in early fibrogenic activation of hepatic stellate cells and fibrosis progression in chronic liver injury.
[Life Sciences]
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Transmembrane Protein 97 Exhibits Oncogenic Properties via Enhancing LRP6-Mediated Wnt Signaling in Breast Cancer

Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
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Pantoprazole Ameliorates Liver Fibrosis and Suppresses Hepatic Stellate Cell Activation in Bile Duct Ligation Rats by Promoting YAP Degradation

Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.
[Acta Pharmacologica Sinica]
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CCT245718, a Dual FLT3/Aurora a Inhibitor Overcomes D835Y-Mediated Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia Cells

The ability of CCT245718 to overcome TKD-mediated resistance was evaluated in a cell line-based model of drug resistance to Fms-like tyrosine kinase 3 (FLT3) inhibitors.
[British Journal of Cancer]
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Drivers and Suppressors of Triple-Negative Breast Cancer

Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
[Proceedings of the National Academy of Sciences of the United States of America]
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